ArticleBMC medical imaging2025
Quantifying anterior segment vascular changes in thyroid eye disease using optical coherence tomography angiography.
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Computational and experimental investigation of nanoparticle effects on tissue optical properties and optical coherence tomography imaging.Biomedical optics express · 2026Article
- Optical coherence tomography angiography in evaluating the response of ocular surface squamous neoplasia to topical immunotherapy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Effects of endoscopic transnasal orbital decompression on anterior segment ocular blood flow and clinical outcome in thyroid-associated ophthalmopathy: a retrospective study.American journal of translational research · 2026Article
- Conjunctival vascularization assessed by AS-OCTA as a biomarker of ocular involvement in primary Sjögren's syndrome.Rheumatology advances in practice · 2026Article
- Conjunctival and retinal microvascular loss in systemic lupus erythematosus: a swept-source OCTA study.Journal of translational medicine · 2025Article
- Choroidal profile in patients with inactive thyroid-associated ophthalmopathy.BMC ophthalmology · 2025Article
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11 authors.
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Abstract
purposeThyroid eye disease (TED) presents challenges in the accurate assessment of disease activity, especially concerning ocular surface manifestations. This study aims to evaluate the potential of anterior segment optical coherence tomography angiography (AS-OCTA) in quantifying vascular changes associated with TED, thereby enhancing understanding of its pathophysiology and aiding in diagnosis and management.
methodsWe conducted a cross-sectional study involving 29 TED patients and 21 healthy controls. Participants underwent comprehensive ophthalmic examination and AS-OCTA imaging of predefined regions of interest (ROI) in the nasal and temporal quadrants. Vascular metrics including vessel density (VD), vessel length density (VLD), vessel diameter index (VDI) and fractal dimension (FD) were analyzed using AS-OCTA software. Disease activity was assessed using clinical activity scores (CAS).
resultsTED patients exhibited increased VD and VLD, particularly in the temporal quadrant, compared to healthy controls. Additionally, TED patients in active disease phases demonstrated larger VDI in the nasal quadrant. Negative correlations were observed between superficial VD and disease activity scores, while positive correlations were found between deep VDI and disease activity.
conclusionAS-OCTA demonstrates potential in quantitatively assessing vascular changes in TED, providing valuable insights into its pathophysiology and potential implications for clinical management. Conjunctival vascular parameters might be valuable in grading the TED disease activity in the future. CLINICAL TRIAL NUMBER: Not applicable.
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