ArticleBMC gastroenterology2025
Clinicopathological features of early-onset colorectal cancer in Japanese patients: a single-center retrospective study.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Interpreting Early-Onset Colorectal Cancer in Japan: A Descriptive Epidemiologic Review Using Public Summary Statistics.Cancer science · 2026Review
- Association between chronic stress-related amygdala metabolic activity and distant metastasis in colorectal cancer.Frontiers in endocrinology · 2026Article
- Combination of Naples prognostic score and pathological factors for evaluating the long-term prognosis of patients with late-onset colorectal cancer: a multicenter machine learning study.Translational cancer research · 2025Article
- Characterization of the mutational landscapes in Japanese patients with early-onset colorectal cancer from comprehensive genomic profiling data.International journal of clinical oncology · 2025Article
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Authors and funding
13 authors.
Funding
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Abstract
backgroundThe incidence of early-onset colorectal cancer (EoCRC), defined as CRC diagnosed at < 50 years of age, is increasing globally. However, only a few studies are reported from Japan, and the clinicopathological features of EoCRC in Japanese patients remain unknown.
methodsWe retrospectively investigated consecutive Japanese patients who were pathologically diagnosed with invasive CRC at our hospital from January 2015 to December 2021. Patients were categorized into those who were diagnosed with CRC at < 50 years (early-onset group) and ≥ 50 years (late-onset group) of age. We compared the clinicopathological findings between the two groups.
resultsThe analysis included 731 patients. EoCRC was diagnosed in 46 patients (6.3% of all patients). Of them, 41.3% demonstrated a positive fecal immunochemical test (FIT) for CRC screening as a diagnostic opportunity, which was significantly higher than that in the late-onset group (p = 0.032). Rectal cancer was significantly more prevalent in the early-onset group compared to the late-onset group (45.7% vs. 26.4%, p < 001). No significant difference in the rate of clinical stage at presentation was found between the two groups. Furthermore, patients with positive FIT were more likely diagnosed at an earlier stage.
conclusionsEoCRC among Japanese patients tends to occur on the rectum and is more frequently diagnosed with FIT screening compared to late-onset CRC. Patients with advanced stage were diagnosed by symptoms, indicating the usefulness of FIT screening in diagnosing EoCRC at an early stage.
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