SynthesisBMC gastroenterology2025
Whether preoperative biliary drainage leads to better patient outcomes of pancreaticoduodenectomy: a meta-analysis and systematic review.
Synthesis in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Preoperative biliary stenting is associated with increased bacterial contamination and postoperative inflammation in pancreatic head resections.BMC surgery · 2026Article
- [Conditioning and systemic treatment before extensive liver resection].Chirurgie (Heidelberg, Germany) · 2026Review
- Diagnosis and Surgical Management for Advanced Pancreatic Cancer Requiring Vascular Resection.Diagnostics (Basel, Switzerland) · 2025Review
- Management of preoperative biliary drainage on postoperative complications and mortality in patients with different degrees of obstructive jaundice undergoing pancreaticoduodenectomy.Annals of hepato-biliary-pancreatic surgery · 2025Article
- A Systematic Review and Meta-Analysis of Preoperative Biliary Drainage Methods in Periampullary Tumors.Journal of clinical medicine · 2025Review
- Review
- Biliary Drainage for the Preoperative Management of Periampullary Neoplasms: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo investigate whether preoperative biliary drainage is beneficial for patients undergoing pancreaticoduodenectomy.
methodsThe PubMed, Cochrane Library and the Web of Science were systematically searched for relevant trials that included outcome of pancreaticoduodenectomy with and without preoperative biliary drainage from January 2010 to May 2024. The primary outcomes are postoperative pancreatic fistula and intra-abdominal infection. Data is pooled using the risk ratio or standardized mean difference with 95% confidence interval. The study protocol was registered prospectively with PROSPERO (CRD42022372584).
resultsA total of 39 retrospective cohort studies with 33,516 patients were included in this trial. Compared with no preoperative biliary drainage, the preoperative biliary drainage group had a longer hospital stay (SMD, 0.14). Performing preoperative biliary drainage significantly increases the risk of postoperative pancreatic fistula (RR, 1.09), intra-abdominal infection (RR, 1.09), surgical site infection (RR, 1.84), and sepsis (RR, 1.37). But preoperative biliary drainage lowers risk of bile leak (RR, 0.74).
conclusionPreoperative biliary drainage before pancreaticoduodenectomy increases the risk of postoperative complications without clear overall benefits. Routine PBD is not recommended for younger patients with mild to moderate jaundice but may be considered for high-risk patients, such as those with severe infections or progressive jaundice. Optimizing preoperative biliary drainage duration and timing may help reduce complications. Further research is needed to refine patient selection and perioperative strategies.
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