Evidence map›Paper›PMID 40069612›Full record

ArticleBMC gastroenterology2025

Identification and validation of a CD4

Mengting Li, Weining Zhu, Yuanyuan Lu, Yu Shao, Fei Xu, Lan Liu, Qiu Zhao

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mengting Li *Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Weining Zhu *Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yuanyuan Lu *Hubei Clinical Center and Key Lab of Intestinal and Colorectal Diseases, Wuhan, China.
Yu ShaoDepartment of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Fei XuDepartment of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China. 328221059@qq.com.
Lan LiuDepartment of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China. lliugi@whu.edu.cn.
Qiu ZhaoDepartment of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China. qiuzhao@whu.edu.cn.

Funding

Fundamental Research Funds for the Central Universities No. 2042023kf0086National Key Clinical Specialty Discipline Construction Program of China No. GJZD2023002Natural Science Foundation of Hubei Province No. 2023AFB203Scientific Research Project of Wuhan Science and Technology Bureau No.2024040801020371
6 · The paper itself

Abstract

backgroundCD4

methodWe combined scRNA and bulk-RNA sequencing to analyze stage III-IV CRC patients and identified the CD4

resultWe found a higher infiltration abundance of activated memory CD4

conclusionThe CD4

Indexed as

CD4-Positive T-LymphocytesColorectal NeoplasmsAgedAnnexin A2Biomarkers, TumorFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisTumor MicroenvironmentAnnexin A2ANXA2 protein, humanBiomarkers, TumorBulk dataCD4+ T cellColorectal cancerPrognostic signaturescRNA-seq

Identifiers

PMID40069612
PMCPMC11895157

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.