Evidence map›Paper›PMID 40069575›Full record

ArticleInternational journal of geriatric psychiatry2025

Economic Implications of Off-Road Cycle Lanes to Increase Physical Activity and Reduce Sex and Gender Differences in the Risk of Dementia.

Magdalena Walbaum, Elisa Aguzzoli, Laura Castro-Aldrete, Eva Cyhlarova, Antonella Santuccione Chadha, Martin Knapp

Abstract read
In one paragraph

Article in International journal of geriatric psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Magdalena WalbaumCare Policy and Evaluation Centre, London School of Economics and Political Science, London, UK.ORCID 0000-0002-2179-9224
Elisa AguzzoliCare Policy and Evaluation Centre, London School of Economics and Political Science, London, UK.
Laura Castro-AldreteWomen's Brain Foundation, Zürich, Switzerland.
Eva CyhlarovaCare Policy and Evaluation Centre, London School of Economics and Political Science, London, UK.
Antonella Santuccione ChadhaWomen's Brain Foundation, Zürich, Switzerland.
Martin KnappCare Policy and Evaluation Centre, London School of Economics and Political Science, London, UK.ORCID 0000-0003-1427-0215

Funding

F. Hoffmann-La Roche
6 · The paper itself

Abstract

backgroundDementia represents one of the greatest global health challenges. There are known risk factors that might prevent or delay nearly 50% of the different types of dementia. There are substantial differences in risk factors and progression of dementia between women and men, including engagement in regular physical activity. The study aimed to quantify the impact of increasing women's participation in physical activity with off-road cycles and its effect on dementia incidence, relative to men and the associated health and social care costs.

methodsOur study employed a population model with secondary data analysis approach to investigate the potential economic effect of implementing off-cycle lanes in the UK. Data were drawn from published evidence on lifetime risk of dementia relative to physical activity in men and women for the UK population, levels of physical activity in the UK, evidence on the effectiveness of off-road cycle lanes in increasing the level of physical activity in men and women, lifetime costs of dementia in the UK. Two scenarios were compared, assuming an increase from the baseline levels of cycling of 40.3% and 114% for women and by 36.4% and 77% for men, respectively. Sensitivity analysis was conducted to account for variations in key variables.

resultsCurrent dementia related lifetime costs were estimated at £1090.1 billion, and total lifetime costs £3326.1 billion. Under Scenario 1, dementia related lifetime costs decreased by £4.7 billion, and total lifetime costs by £0.11 billion. In Scenario 2, dementia related lifetime costs decreased by £7.0 billion, and total lifetime costs by £1.9 billion.

conclusionOff-road cycle lanes, especially for women, this type of structural and lifestyle intervention has the potential to bring health and economic benefits. Increased physical activity not only provides numerous health benefits, but also contributes to preventing the onset and lifetime costs of dementia.

Indexed as

BicyclingDementiaExerciseAgedAged, 80 and overFemaleHealth Care CostsHumansMaleMiddle AgedRisk FactorsSex FactorsUnited Kingdomdementiaeconomic impactoff‐road cycle lanephysical activitysex and gender differences

Identifiers

PMID40069575
PMCPMC11896945

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.