Evidence map›Paper›PMID 40069564›Full record

ArticleNature chemistry2025

Aryl halide cross-coupling via formate-mediated transfer hydrogenation.

Yoon Cho, Yu-Hsiang Chang, Kevin P Quirion, Zachary H Strong, Zachary J Dubey, Nam Nguyen, Seoyoung Lee, Natalie S Taylor, Jessica M Hoover, Nicholas A White and 2 more

Abstract read
In one paragraph

Article in Nature chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yoon Cho *Department of Chemistry, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0002-3550-6699
Yu-Hsiang Chang *Department of Chemistry, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0003-1000-135X
Kevin P Quirion *Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-1599-9422
Zachary H Strong *Department of Chemistry, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0003-3367-2906
Zachary J DubeyDepartment of Chemistry, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0003-3009-5947
Nam NguyenDepartment of Synthetic Molecule Process Chemistry, Genentech, South San Francisco, CA, USA.
Seoyoung LeeDepartment of Chemistry, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0009-0002-8871-5256
Natalie S TaylorDepartment of Chemistry, University of Minnesota-Twin Cities, Minneapolis, MN, USA.ORCID http://orcid.org/0009-0000-1454-8999
Jessica M HooverDepartment of Chemistry, University of Minnesota-Twin Cities, Minneapolis, MN, USA. jmhoover@umn.edu.ORCID http://orcid.org/0000-0003-0254-5090
Nicholas A WhiteDepartment of Synthetic Molecule Process Chemistry, Genentech, South San Francisco, CA, USA. white.nicholas@gene.com.ORCID http://orcid.org/0000-0001-5038-8865
Peng LiuDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA. pengliu@pitt.edu.ORCID http://orcid.org/0000-0002-8188-632X
Michael J KrischeDepartment of Chemistry, University of Texas at Austin, Austin, TX, USA. mkrische@cm.utexas.edu.ORCID http://orcid.org/0000-0001-8418-9709

Funding

Substituted Piperidine Formation via C-C Bond Forming Transfer HydrogenationR01GM069445 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI KRISCHE, MICHAEL J · 2005 to 2024
$6.7M
Computational Models for Reactivity and Selectivity in Transition Metal-Catalyzed Olefin FunctionalizationR35GM128779 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peng Liu · 2018 to 2026
$2.9M
Understanding Coupling Reactions of HeteroarylsR35GM133566 · NIGMS · WEST VIRGINIA UNIVERSITY · PI HOOVER, JESSICA M · 2019 to 2023
$1.3M
Catalytic C-C Coupling via Hydrogen TransferR35GM155947 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI MICHAEL J KRISCHE · 2025 to 2026
$1.1M
Upgrade of a 500 MHz NMR Spectrometer for Applications in Biomedical ResearchS10OD011952 · OD · UNIVERSITY OF MINNESOTA · PI HOYE, THOMAS R. · 2012 to 2012
$378k
National Science Foundation (NSF) CHE-1336940National Science Foundation (NSF) OAC-1928147National Science Foundation (NSF) OAC-1928224National Science Foundation (NSF) OAC-2117681NIGMS NIH HHS R01 GM069445NIGMS NIH HHS R35 GM128779NIGMS NIH HHS R35 GM133566NIGMS NIH HHS R35 GM155947NIH HHS S10 OD011952U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM-133566U.S. Department of Health & Human Services | National Institutes of Health (NIH) RO1-GM069445U.S. Department of Health & Human Services | National Institutes of Health (NIH) S10OD011952Welch Foundation F-0038
6 · The paper itself

Abstract

Transfer hydrogenation is widely practised across all segments of chemical industry, yet its application to aryl halide reductive cross-coupling is undeveloped because of competing hydrogenolysis. Here, exploiting the distinct reactivity of Pd

Identifiers

PMID40069564
PMCPMC12308758

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.