Evidence map›Paper›PMID 40069518›Full record

ArticleJournal of patient-reported outcomes2025

Establishing content validity of the Dimensional Anhedonia Rating Scale.

Stephanie Bean, Rahul Dhanda, Christina A Graham, Deborah Hoffman, Mariam Rodriguez-Lee, Adrian Ionescu, Stella Karantzoulis, Sidney H Kennedy, Sakina J Rizvi

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In one paragraph

Article in Journal of patient-reported outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stephanie BeanPatient Centered Solutions, IQVIA, 600 Lexington Avenue, New York, NY, 10022, USA.
Rahul DhandaNeurocrine Biosciences, Inc., 12780 El Camino Real, San Diego, CA, 92130, USA. rdhanda41@gmail.com.ORCID http://orcid.org/0000-0002-6941-3853
Christina A GrahamPatient Centered Solutions, IQVIA, 600 Lexington Avenue, New York, NY, 10022, USA.
Deborah HoffmanTakeda Pharmaceutical Company, 650 E Kendall St, Cambridge, MA, 02142, USA.
Mariam Rodriguez-LeeNeurocrine Biosciences, Inc., 12780 El Camino Real, San Diego, CA, 92130, USA.
Adrian IonescuNeurocrine Biosciences, Inc., 12780 El Camino Real, San Diego, CA, 92130, USA.
Stella KarantzoulisPatient Centered Solutions, IQVIA, 600 Lexington Avenue, New York, NY, 10022, USA.
Sidney H KennedyDepartment of Psychiatry, University of Toronto, 27 King's College Circle, Toronto,, ON M5S, Canada.
Sakina J RizviDepartment of Psychiatry, University of Toronto, 27 King's College Circle, Toronto,, ON M5S, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study was designed to evaluate content validity of the Dimensional Anhedonia Rating Scale (DARS), a patient-reported outcome measure, in adults with anhedonia in the context of major depressive disorder (MDD). To accomplish this, a conceptual model including the symptoms and impacts of anhedonia in the context of MDD was developed and refined through a targeted literature review, clinician interviews (N = 6), and participant interviews (N = 20).

resultsUsing the final conceptual model, an item mapping exercise was conducted for the DARS, demonstrating that it provided suitable concept coverage in this population. Cognitive debriefing of the DARS with participants demonstrated that it was generally well understood and clear.

conclusionsOverall, the study established that the DARS demonstrates content validity in adults with anhedonia in the context of MDD. Other measurement properties of the DARS will be evaluated in planned psychometric analyses.

Indexed as

AnhedoniaMajor Depressive DisorderPatient Reported Outcome MeasuresPsychiatric Status Rating ScalesAdultFemaleHumansMaleMiddle AgedPsychometricsReproducibility of ResultsYoung AdultAnhedoniaCognitive debriefing (CD)Concept elicitation (CE)Conceptual modelContent validityDimensional Anhedonia Rating Scale (DARS)Major depressive disorder (MDD)Qualitative interviews

Identifiers

PMID40069518
PMCPMC11896914

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.