Evidence map›Paper›PMID 40069498›Full record

ReviewJournal of human genetics2025

Molecular gene signature of circulating stromal/stem cells.

Weiping Lin, Liangliang Xu, Gang Li, Micky Daniel Tortorella

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of human genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Weiping LinCentre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong, SAR, China.
Liangliang XuKey Laboratory of Orthopaedics & Traumatology, Lingnan Medical Research Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, Guangzhou, China. xull-2016@gzucm.edu.cn.
Gang LiDepartment of Orthopaedics & Traumatology, Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, Lui Che Woo Institute of Innovative Medicine, Faculty of Medicine, Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, SAR, China. gangli@cuhk.edu.hk.
Micky Daniel TortorellaCentre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong, SAR, China. m.tortorella@gibh.org.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82172430
6 · The paper itself

Abstract

The human skeleton is renewed and regenerated throughout life, by a cellular process known as bone remodeling. Stem cells are clono-genic cells that are capable of differentiation into multiple mature cell types (multipotency), and simultaneously replenishing stem cell pool (self-renewal), which allows them to sustain tissue development and maintenance. Circulating mesenchymal stromal/stem cells (MSCs), are mobile adult stem cells with specific gene expression profiling, as well as enhanced mitochondrial remodeling as a promising source for personalized cell and gene therapy. A global LGR5-associated genetic interaction network highlights the functional organization and molecular phenotype of circulating MSCs.

Indexed as

Mesenchymal Stem CellsTranscriptomeCell DifferentiationGene Expression ProfilingHumansReceptors, G-Protein-CoupledLGR5 protein, humanReceptors, G-Protein-Coupled

Identifiers

PMID40069498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.