Evidence map›Paper›PMID 40069483›Full record

ArticlePediatric research2025

Improved linear growth after routine zinc supplementation in preterm very low birth weight infants.

Tina A Seidu, Luc P Brion, Roy Heyne, L Steven Brown, Theresa Jacob, Audrey Edwards, Cheryl S Lair, Myra H Wyckoff, David B Nelson, Dimitrios Angelis

Abstract read
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In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tina A SeiduDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Luc P BrionDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Roy HeyneDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
L Steven BrownParkland Health, Dallas, TX, USA.
Theresa JacobParkland Health, Dallas, TX, USA.
Audrey EdwardsParkland Health, Dallas, TX, USA.
Cheryl S LairParkland Health, Dallas, TX, USA.
Myra H WyckoffDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
David B NelsonDepartment of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Dimitrios AngelisDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. Dimitrios.Angelis@UTSoutwestern.edu.ORCID http://orcid.org/0000-0002-1071-1960

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study was designed (1) to compare growth, morbidity and mortality in < 33-week gestational age (GA) (very preterm, VPT) or very low birth weight (BW < 1500 grams, VLBW) infants before (Epoch-1) and after implementing routine enteral zinc (Zn) supplementation (Epoch-2) to meet recommendations, and (2) to assess serum Zn levels and associated variables.

methodsSingle-center prospective cohort of 826 infants. The primary outcome was the change (Δ) in Z-scores of accurate length (Δlength

resultsIn Epoch-2 vs Epoch-1 Δlength

conclusionRoutine enteral Zn supplementation was independently associated with improved linear growth but did not prevent occurrence of low Zn. ROP was independently associated with the lowest Zn. IMPLICATIONS: Multicenter studies are needed to assess whether dosage of enteral Zn should be increased and whether Zn could help prevent ROP. IMPACT: Implementation of routine enteral zinc (Zn) supplementation was associated with improved linear growth from birth to discharge and a more frequent physiologic growth curve in preterm very low birth weight infants. Serum Zn levels decreased with gestational age and with postnatal age. Low serum Zn levels were observed frequently despite routine Zn supplementation as currently recommended, which suggests a need to re-evaluate current enteral zinc supplementation guidelines for this population. Retinopathy of prematurity among infants < 33 weeks' gestation was independently associated with low gestational age, low birthweight, stage of bronchopulmonary dysplasia and the lowest serum Zn level.

Indexed as

Dietary SupplementsInfant, PrematureInfant, Very Low Birth WeightZincEnteral NutritionFemaleGestational AgeHumansInfant, NewbornMaleProspective StudiesRetinopathy of PrematurityZinc

Identifiers

PMID40069483
PMCPMC12549326

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