Evidence map›Paper›PMID 40069457›Full record

Trial reportEuropean journal of nuclear medicine and molecular imaging2025

Alternative treatment for recurrent keloids: initial clinical experience with Rhenium-188 using a specialized device.

Kgomotso M G Mokoala, Linda Nonjola, Thabiso Moeng, Cecilia Corbett, Martin Magwaza, Gerhard Dahlhoff, Shannon Brown, Nicholas Vetter, Mariza Vorster, Mike Machaba Sathekge

Abstract readClinical Trial
In one paragraph

Trial report in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. TargetedFrontiers in medicine · 2025
    Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kgomotso M G MokoalaDepartment of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa.
Linda NonjolaDepartment of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa.
Thabiso MoengDepartment of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa.
Cecilia CorbettDepartment of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa.
Martin MagwazaOncobeta Africa and Tautomer Biosciences, Pretoria, South Africa.
Gerhard DahlhoffOncobeta GmbH, Munchen, Munich, Germany.
Shannon BrownOncobeta GmbH, Munchen, Munich, Germany.
Nicholas VetterOncobeta GmbH, Munchen, Munich, Germany.
Mariza VorsterNuclear Medicine Research Infrastructure (NuMeRI), Pretoria, South Africa.
Mike Machaba SathekgeDepartment of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa. mike.sathekge@up.ac.za.ORCID 0000-0002-2806-0625

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionKeloids have proved challenging to manage with various therapies providing variable success rates and recurrences. Alternative therapies or a multimodal approach is often necessary to ensure complete eradication and prevent recurrence. The use of radioactive creams or patches embedded with Holmium-166, Phosphorus-32 for superficial skin lesions has been documented to be safe and effective. The use of Rhenium-188 has proved effective in non-melanoma skin cancers. We report on the initial experience with Rhenium-188 SCT in the treatment of recurrent keloid lesions.

methodsPatients with recurrent keloid lesions were recruited for therapy with Rhenium-188. These patients had failed most forms of therapy including surgery, intralesional steroids and radiation therapy. Treatment with

resultsA total of 58 lesions were treated. Majority of the lesions were in the head and neck region. The smallest area for treatment was 0.25cm

conclusionTreatment with CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

KeloidRadioisotopesRheniumAdultAgedFemaleHumansMaleMiddle AgedRecurrenceTreatment OutcomeRadioisotopesRheniumRhenium-188188ReKeloidsRhenium SCTSingle session therapy

Identifiers

PMID40069457
PMCPMC12222312

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.