Evidence map›Paper›PMID 40069426›Full record

SynthesisQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2025

A patient first perspective of sleep disturbance across therapeutic areas: a systematic literature review of qualitative studies.

Kyle Riedmann, Sean Gay, Sarah Averill Lott, Jonathan Berent, Derek L Buhl, Joseph M Dzierzewski, Nina Shaafi Kabiri, Frank Kramer, Michael Kremliovsky, Christian Seitz and 4 more

Abstract readSystematic Review
In one paragraph

Synthesis in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kyle Riedmann *Digital Medicine Society, Boston, MA, USA.
Sean Gay *Digital Medicine Society, Boston, MA, USA.
Sarah Averill LottDigital Medicine Society, Boston, MA, USA. sarah.lott@dimesociety.org.ORCID http://orcid.org/0009-0004-0508-2487
Jonathan BerentNextSense, Inc, Mountain View, CA, USA.
Derek L BuhlAbbvie, Inc., North Chicago, IL, USA.
Joseph M DzierzewskiNational Sleep Foundation, Washington, DC, USA.
Nina Shaafi KabiriBoston University Chobanian, Boston, MA, USA.
Frank KramerBAYER Pharmaceuticals AG, Wuppertal, Germany.
Michael KremliovskyBayer US LLC, Whippany, NJ, USA.
Christian SeitzBayer AG, Berlin, Germany.
Dries TestelmansDepartment of Pneumology, University Hospitals Leuven, Leuvan, Belgium.
Kevin ThomasBoston University Chobanian, Boston, MA, USA.
Herman de VriesDepartment of Learning and Workforce Development, The Netherlands Organization for Applied Research, Soesterberg, Netherlands.
Piper FromyDigital Medicine Society, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSleep, a vital pillar of health, impacts daily functioning and overall quality of life. Despite extensive research on sleep disturbances within specific therapeutic areas (TAs), there's limited understanding of how these disturbances affect patients across multiple TAs. This systematic literature review adopts a patient-centered approach to explore the meaningful aspects of health and concepts of interest relating to sleep and sleep disturbances across a variety of TAs, utilizing qualitative research to bridge the gap between patient experiences and clinical measures.

methodsA systematic search was conducted in Embase and PubMed for qualitative studies on sleep within selected TAs, using a pre-registered strategy. Initial screenings based on titles and abstracts were followed by full-text reviews and quality appraisal using the CASP checklist.

resultsFrom 4331 unique publications, 52 full-text articles were analyzed across 11 TAs. Thematic analysis highlighted issues within the sleep window, and proximal and distal impacts of sleep disturbances. Using thematic analysis a conceptual model was developed, illustrating a multitude of sleep disturbances from a patient-first perspective, which emphasized sleep quality's role in daily functionality. DISCUSSION: This review emphasizes the importance of incorporating patient perspectives into sleep research and clinical practice. By presenting a holistic conceptual model, it provides a foundation for developing outcome measures that reflect meaningful aspects of patients' sleep experiences. This patient-centered approach highlights the need for novel methodologies in sleep research, beyond traditional clinical outcome assessments, to capture the full spectrum of sleep disturbances' impacts on patients' lives across various TAs.

Indexed as

Quality of LifeSleep Wake DisordersHumansQualitative ResearchSleep QualityBroad sleep quality issuesPatient perspectiveQualitative sleep reviewSleep

Identifiers

PMID40069426
PMCPMC12182499

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.