Evidence map›Paper›PMID 40069381›Full record

ReviewAnalytical and bioanalytical chemistry2025

Advances in carcinoembryonic antigen detection: a review of clinical applications and standardization.

Haofeng Sun, Jianyi Liu, Qi Zhang, Lei Yang, Min Zhou, Dewei Song

Abstract readReview
PubMed Publisher
In one paragraph

Review in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. A high-affinity CEA-targeted nanobody forJournal of nanobiotechnology · 2025
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haofeng SunSchool of Chemical and Engineering, Nanjing University of Science and Technology, Jiangsu, 210094, China.
Jianyi LiuDivision of Chemical Metrology and Analytical Science, National Institute of Metrology (Key Laboratory of Chemical Metrology and Applications On Nutrition and Health for State Market Regulation), Beijing, 100029, China.
Qi ZhangDivision of Chemical Metrology and Analytical Science, National Institute of Metrology (Key Laboratory of Chemical Metrology and Applications On Nutrition and Health for State Market Regulation), Beijing, 100029, China.
Lei YangDivision of Chemical Metrology and Analytical Science, National Institute of Metrology (Key Laboratory of Chemical Metrology and Applications On Nutrition and Health for State Market Regulation), Beijing, 100029, China.
Min ZhouSchool of Chemical and Engineering, Nanjing University of Science and Technology, Jiangsu, 210094, China. minzhou@njust.edu.cn.
Dewei SongDivision of Chemical Metrology and Analytical Science, National Institute of Metrology (Key Laboratory of Chemical Metrology and Applications On Nutrition and Health for State Market Regulation), Beijing, 100029, China. songdw@nim.ac.cn.

Funding

National Key Research and Development Program of China 2022YFF0710301Yangtze River Delta Science and Technology Innovation Community Joint Research Project 2023CSJGG1800
6 · The paper itself

Abstract

Carcinoembryonic antigen (CEA) is among the earliest identified tumor markers and remains extensively utilized in the diagnosis and management of colorectal cancer. The detection of CEA presents considerable challenges in the field of analytical chemistry, given its complexity. The most prevalent detection approach is the immunoassay, including the chemiluminescence immunoassay commonly employed in clinical settings; however, discrepancies between various methods persist. Mass spectrometry-based techniques offer enhanced accuracy as they circumvent matrix interference. Nonetheless, the intricate nature of proteins continues to pose significant challenges. This paper reviews recent advancements in CEA detection technologies, examines their clinical application potential from two key platforms, and addresses the standardization process of CEA detection. This paper highlights the importance of developing rapid and precise methods for CEA analysis in complex matrices and their standardization.

Indexed as

Biomarkers, TumorCarcinoembryonic AntigenColorectal NeoplasmsHumansImmunoassayMass SpectrometryBiomarkers, TumorCarcinoembryonic AntigenCEAHarmonizationImmunoassaysIVD reagentsMass spectrometry

Identifiers

PMID40069381

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.