Evidence map›Paper›PMID 40069335›Full record

ArticleScientific reports2025

Associations of essential trace metals with telomere length in general population: a cross-sectional study.

Jiahui Rong, Qiumei Liu, Tiantian Zhang, Yufu Lu, Zeyan Ye, Kaisheng Teng, Lei Luo, Songju Wu, Linhai Zhao, Wenjia Jin and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jiahui Rong *Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, PR China.
Qiumei Liu *Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, PR China.
Tiantian Zhang *Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, PR China.
Yufu LuDepartment of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, PR China.
Zeyan YeDepartment of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin, PR China.
Kaisheng TengDepartment of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, PR China.
Lei LuoDepartment of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, PR China.
Songju WuDepartment of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, PR China.
Linhai ZhaoDepartment of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, PR China.
Wenjia JinDepartment of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, PR China.
Qinyi GuanDepartment of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, PR China.
You LiDepartment of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin, PR China.
Jian QinDepartment of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, PR China.
Jiansheng CaiDepartment of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin, PR China. 15007714226@163.com.
Zhiyong ZhangDepartment of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, PR China. rpazz@163.com.

Funding

he National Natural Science Foundation of China 81960583Innovation Platform and Talent Plan in Guilin 20220120-2Open Project of Key Laboratory of Longevity and Aging-related Diseases(Guangxi Medical University), Ministry of Education KLLAD202304the Guangxi Natural Science Foundation for Innovation Research Team 2019GXNSFGA245002the National Natural Science Foundation of China 82260629The study was supported by the Major Science and Technology Projects in Guangxi AA22096026Xinghu Scholars Program of Guangxi Medical University，the Open Project Program of Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guilin Medical University 2022-GKLEH-02
6 · The paper itself

Abstract

This study investigated the relationship between essential plasma metals (Co, Cr, Cu, Mn, Mo, Se, Zn) and telomere length in 2,194 Chinese adults aged ≥ 30 years. Metal concentrations were measured using ICP-MS, and leukocyte relative telomere length (rTL) was assessed by qPCR. In the elderly, Cr and Mn were significantly positively correlated with rTL, while Mo, Zn, and Cu showed negative correlations. In the 30-59 age group, the overall metal mixture was significantly negatively associated with rTL (estimate = -0.069, P = 0.003), with Zn as the dominant contributor. In the elderly, the metal mixture was positively associated with rTL (estimate = 0.040, P = 0.031), with Cr and Mn as main contributors. The findings highlight the importance of maintaining adequate Cr and Mn levels in older adults, and the potential adverse impact of Cu, Mo, and Zn on telomere length.

Indexed as

TelomereTelomere HomeostasisTrace ElementsAdultAgedAged, 80 and overCross-Sectional StudiesFemaleHumansLeukocytesMaleMiddle AgedTrace ElementsBKMRQuantile g-computationTelomere lengthTrace metal

Identifiers

PMID40069335
PMCPMC11897380

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.