Evidence map›Paper›PMID 40069327›Full record

ArticleCommunications biology2025

Genome-wide mapping and quantification of DNA damage induced by catechol estrogens using Click-Probe-Seq and LC-MS

Quynh-Trang Do, Shun-Fen Tzeng, Chih-Yen Wang, Chih-Hsing Wu, Husam Kafeenah, Shu-Hui Chen

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Quynh-Trang DoDepartment of Chemistry, National Cheng Kung University, Tainan, Taiwan.
Shun-Fen TzengDepartment of Life Sciences, National Cheng Kung University, Tainan, Taiwan.
Chih-Yen WangDepartment of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.ORCID http://orcid.org/0009-0008-8270-6491
Chih-Hsing WuInstitute of Gerontology, National Cheng Kung University, Tainan, Taiwan.
Husam KafeenahDepartment of Chemistry, National Cheng Kung University, Tainan, Taiwan.
Shu-Hui ChenDepartment of Chemistry, National Cheng Kung University, Tainan, Taiwan. shchen@mail.ncku.edu.tw.ORCID http://orcid.org/0000-0003-1871-9366

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genotoxic estrogen metabolites generate various DNA lesions; however, their target genes and carcinogenic mechanisms remain unexplored. Here, genome-wide sequencing using click probe enrichment coupled with liquid chromatography-tandem mass spectrometry (Click-Probe-Seq/LC-MS

Indexed as

Chromosome MappingDNA DamageEstrogens, CatecholChromatinChromatography, LiquidDNA AdductsHumansMCF-7 CellsTandem Mass SpectrometryChromatinDNA AdductsEstrogens, Catechol

Identifiers

PMID40069327
PMCPMC11897211

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.