ArticleScientific reports2025
A novel index evaluating left atrioventricular coupling function in chronic kidney disease with diabetes patients.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Left Atrioventricular Coupling Index: A Comprehensive Review of the Literature.Life (Basel, Switzerland) · 2026Review
- Left atrial reservoir strain and the left atrioventricular coupling index in association with left ventricular diastolic dysfunction in non-dialysis chronic kidney disease with preserved ejection fraction: a cross-sectional study.BMC cardiovascular disorders · 2026Article
- Echocardiographic assessment of left atrioventricular coupling index: technical approaches and clinical implementation strategies.Frontiers in cardiovascular medicine · 2026Review
- Prognostic value of left atrioventricular coupling index in patients undergoing transcatheter aortic valve implantation: a prospective echocardiographic study.Quantitative imaging in medicine and surgery · 2025Article
- Clinical Utility of Atrioventricular Coupling Index in Cardiovascular Disease.Journal of the American Heart Association · 2025Review
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Authors and funding
10 authors.
Funding
Abstract
The left atrioventricular coupling index (LACI) evaluates the coupling function between the left atrial (LA) and left ventricular (LV) chambers. However, little is known about LACI in chronic kidney disease (CKD) patients. This study aimed to assess the impact of concurrent CKD and type 2 diabetes mellitus (T2DM) on left atrioventricular coupling function compared to CKD patients without T2DM. A retrospective analysis included 173 CKD 4-5 stage patients who underwent echocardiographic examinations. The study comprised 75 CKD patients with T2DM (CKD + DM) and 98 CKD patients without T2DM (CKD-DM). During the follow-up, major adverse cardiac events (MACE) were tracked until June 30, 2024, or death, with a median duration of 21 (18, 27) months, 20.8% of patients experienced MACE, and 10.4% passed away. This study employed speckle tracking echocardiography to evaluate LA and LV strain, alongside the LACI, analyzing its role in predicting MACE. CKD + DM patients showed a notable rise in LACI compared to CKD-DM patients, hinting at a link between diabetes and impaired left atrioventricular coupling in CKD. Patients with lower LACI had superior clinical outcomes during follow-up (P < 0.001). Univariate and multivariate Cox regression analyses underscored LACI as an independent predictor for heightened MACE risk in CKD 4-5 stage patients. This study highlights a potential association between diabetes and impaired left atrioventricular coupling function in CKD 4-5 stage patients, with LACI independently linked to an increased risk of MACE.
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