Evidence map›Paper›PMID 40069248›Full record

ArticleScientific reports2025

Novel 5-HT

José Miguel Alcaíno, Gonzalo Vera, Gonzalo Almarza, Carlos F Lagos, Claudio A Terraza, Andrea Del Campo, Gonzalo Recabarren-Gajardo

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

José Miguel Alcaíno *Laboratorio de Fisiología y Bioenergética Celular, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, 7810000, Chile.
Gonzalo Vera *Bioactive Heterocycles Synthesis Laboratory (BHSL), Departamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Avenida Vicuña Mackenna, Macul, Santiago, 4860, 7820436, Chile.
Gonzalo AlmarzaLaboratorio de Fisiología y Bioenergética Celular, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, 7810000, Chile.
Carlos F LagosChemical Biology & Drug Discovery Lab, Escuela de Química y Farmacia, Facultad de Medicina y Ciencia, Universidad San Sebastián, Campus Los Leones, Providencia, Lota, Santiago, 2465, 7510157, Chile.
Claudio A TerrazaResearch Laboratory for Organic Polymers (RLOP), Faculty of Chemistry and of Pharmacy, Pontificia Universidad Católica de Chile, Post 22, P.O. Box. 306, Santiago, Chile.
Andrea Del CampoLaboratorio de Fisiología y Bioenergética Celular, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, 7810000, Chile. andrea.delcampo@uc.cl.
Gonzalo Recabarren-GajardoBioactive Heterocycles Synthesis Laboratory (BHSL), Departamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Avenida Vicuña Mackenna, Macul, Santiago, 4860, 7820436, Chile. grecabarren@uc.cl.

Funding

Agencia Nacional de Investigación y Desarrollo,Chile 1241192Agencia Nacional de Investigación y Desarrollo,Chile FONDECYT 1230428
6 · The paper itself

Abstract

Autophagy is a natural process in which the cell degrades substances through the lysosomal pathway. One of the most studied mechanisms for regulating autophagy is the mTOR signaling pathway. Recent research has shown that the 5-HT

Indexed as

AutophagyNeuronsReceptors, SerotoninSerotonin AntagonistsTOR Serine-Threonine KinasesCell Line, TumorCell SurvivalHumansIndazolesIndolesSignal TransductionIndazolesIndolesMTOR protein, humanReceptors, Serotoninserotonin 6 receptorSerotonin AntagonistsTOR Serine-Threonine Kinases5-HT6RAutophagyModulatorsmTOR

Identifiers

PMID40069248
PMCPMC11897353

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.