Evidence map›Paper›PMID 40069180›Full record

ArticleNature communications2025

PGRMC2 is a pressure-volume regulator critical for myocardial responses to stress in mice.

Farideh Amirrad, Vivian La, Sharareh Ohadi, Miram Albotaif, Sha Webster, James K Pru, Kiumars Shamloo, Ashraf M Mohieldin, Surya M Nauli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. UterineCancers · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Farideh AmirradDepartment of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-0919-7634
Vivian LaDepartment of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, USA.
Sharareh OhadiDepartment of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, USA.
Miram AlbotaifDepartment of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, USA.
Sha WebsterDepartment of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, USA.
James K PruDepartment of Animal Sciences, University of Wyoming, Laramie, WY, USA.
Kiumars ShamlooDepartment of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-4757-1033
Ashraf M MohieldinDepartment of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, USA.
Surya M NauliDepartment of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, USA. nauli@chapman.edu.ORCID http://orcid.org/0000-0001-9787-1053

Funding

The roles of neuronal primary cilia in Alzheimer's diseaseR01HL147311 · NHLBI · CHAPMAN UNIVERSITY · PI NAULI, SURYA · 2020 to 2023
$2.1M
The signaling mechanism of primary cilia in aneurysm preventionR56HL131577 · NHLBI · CHAPMAN UNIVERSITY · PI NAULI, SURYA · 2017 to 2017
$345k
NHLBI NIH HHS R01 HL147311NHLBI NIH HHS R56 HL131577U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL131577
6 · The paper itself

Abstract

Progesterone receptors are classified into nuclear and membrane-bound receptor families. Previous unbiased proteomic studies indicate a potential association between cardiac diseases and the progesterone receptor membrane-bound component-2 (PGRMC2); however, the role of PGRMC2 in the heart remains unknown. In this study, we use a heart-specific knockout (KO) mouse model (MyH6•Pgrmc2

Indexed as

Membrane ProteinsMyocardiumMyocytes, CardiacReceptors, ProgesteroneStress, PhysiologicalAnimalsCalcium SignalingFemaleHeartHypoxiaMaleMiceMice, Inbred C57BLMice, KnockoutMyocardial ContractionStroke VolumeMembrane ProteinsReceptors, Progesterone

Identifiers

PMID40069180
PMCPMC11897200

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.