ArticleThe Prostate2025
Propensity Score Matched Analysis of External Beam Radiotherapy With or Without Focal Boost to Intraprostatic Lesions in Prostate Cancer.
Article in The Prostate, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Article
- External beam focal boost radiotherapy to intraprostatic lesions in prostate cancer: a scoping review.Physics and imaging in radiation oncology · 2026Review
- Does transurethral resection of prostate increase toxicity risk after simultaneous integrated boost radiotherapy? A matched cohort study with long-term follow-up.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThis study evaluated the impact of radiotherapy (RT) with or without a simultaneous integrated boost (SIB) to intraprostatic lesions on survival, recurrence, and toxicity in localized prostate cancer (PCa). Key prognostic and predictive factors were also analyzed. MATERIALS AND
methodsA retrospective analysis included 712 intermediate- and high-risk PCa patients treated with external beam RT at 78 Gy, with or without SIB (up to 86 Gy), between 2010 and 2018. Propensity score matching (PSM) was used to ensure comparability. Outcomes assessed included biochemical disease-free survival (bDFS), prostate cancer-specific survival (PCSS), local recurrence (LR), distant metastasis (DM), and treatment-related toxicities.
resultsAfter PSM, 417 patients were analyzed (208 with SIB, 209 without). Over a median follow-up of 8.6 years, the SIB group showed higher 8-year bDFS (93.8% vs. 83.5%; p = 0.006) and lower rates of DM (6.1% vs. 13.0%; p = 0.003) and LR (1.8% vs. 6.9%; p = 0.03). PCSS was similar between groups (95.7% vs. 92.3%; p = 0.38). Advanced T stage and absence of SIB were predictors of worse bDFS, DM, and LR, while higher Gleason score were associated with poorer PCSS and DM in multivariable analysis. There were no significant differences in 8-year Grade ≥ 2 GU (10.1% vs. 10.5%; p = 0.98) or GI (7.8% vs. 6.5%; p = 0.64) toxicities between the SIB and non-SIB groups.
conclusionsSIB with external beam RT significantly improves bDFS and reduces LR and DM in intermediate- and high-risk PCa, with no increase in significant toxicities. These findings emphasize the value of dose escalation in achieving better local control and long-term outcomes while maintaining patient safety.
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