Evidence map›Paper›PMID 40068818›Full record

ArticleNature2025

Complex water networks visualized by cryogenic electron microscopy of RNA.

Rachael C Kretsch, Shanshan Li, Grigore Pintilie, Michael Z Palo, David A Case, Rhiju Das, Kaiming Zhang, Wah Chiu

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Comparative Evaluation of Explicit Solvent Models for RNA-Ligand Docking.Journal of chemical information and modeling · 2026
    Article
  6. Article
  7. Article
  8. Direct evidence of acid-driven protein desolvation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Blind prediction of complex water and ion ensembles around RNA in CASP16.bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Rachael C Kretsch *Biophysics Program, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6935-518X
Shanshan Li *Department of Urology, The First Affiliated Hospital of USTC, MOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID 0000-0002-7041-5960
Grigore Pintilie *Department of Bioengineering and James Clark Center, Stanford University School of Medicine, Stanford, CA, USA.
Michael Z PaloDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-4883-6766
David A CaseDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, USA.
Rhiju DasBiophysics Program, Stanford University School of Medicine, Stanford, CA, USA. rhiju@stanford.edu.ORCID 0000-0001-7497-0972
Kaiming ZhangDepartment of Urology, The First Affiliated Hospital of USTC, MOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. kmzhang@ustc.edu.cn.ORCID 0000-0003-0414-4776
Wah ChiuBiophysics Program, Stanford University School of Medicine, Stanford, CA, USA. wahc@stanford.edu.ORCID 0000-0002-8910-3078

Funding

The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8M
Unified Data Resource for Large Complexes Determined by Cryo-Electron MicroscopyR01GM079429 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH · 2007 to 2021
$11.6M
Next-generation computational/chemical methods for complex RNA structuresR35GM122579 · NIGMS · STANFORD UNIVERSITY · PI Rhiju Das · 2017 to 2026
$7.2M
NIGMS NIH HHS R01 GM079429NIGMS NIH HHS R35 GM122579NIGMS NIH HHS U24 GM129541
6 · The paper itself

Abstract

The stability and function of biomolecules are directly influenced by their myriad interactions with water

Indexed as

Cryoelectron MicroscopyRNA, CatalyticWaterMagnesiumModels, MolecularMolecular Dynamics SimulationTetrahymenaTetrahymena thermophilaMagnesiumRNA, CatalyticWater

Identifiers

PMID40068818
PMCPMC12137144

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.