Evidence map›Paper›PMID 40068771›Full record

ArticleJournal of molecular and cellular cardiology2025

Ca

Xutu Wang, Nathan Kallish, R John Solaro, Wen-Ji Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Evidence for a role of adverse sarcomere signaling in atrial fibrillation induction.Journal of molecular and cellular cardiology plus · 2026
    Review
  2. A new era of understanding of the control of thick filament states in the heartbeat.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xutu WangVoiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA 99163-1062, USA.
Nathan KallishVoiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA 99163-1062, USA.
R John SolaroDepartment of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612-7342, USA.
Wen-Ji DongVoiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA 99163-1062, USA; Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA 99163-1062, USA. Electronic address: dongwenji@wsu.edu.

Funding

Sarcomeric Modifications and Progressive Cardiac MaladaptationP01HL062426 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SOLARO, R JOHN · 2000 to 2020
$42.4M
Kinetics of Cardiac Myofilament ActivationR01HL080186 · NHLBI · WASHINGTON STATE UNIVERSITY · PI DONG, WEN-JI · 2005 to 2013
$3.4M
Structural Kinetics of Thin Filament Regulation at Single Molecule LevelR21HL109693 · NHLBI · WASHINGTON STATE UNIVERSITY · PI DONG, WEN-JI · 2013 to 2014
$388k
NHLBI NIH HHS P01 HL062426NHLBI NIH HHS R01 HL080186NHLBI NIH HHS R21 HL109693
6 · The paper itself

Abstract

Sarcomere length-dependent activation (LDA) is the key cellular mechanism underlying the Frank-Starling law of the heart, in which sarcomere stretch leads to increased Ca

Indexed as

ActinsCalciumCarrier ProteinsMyosinsSarcomeresAnimalsMyocardial ContractionMyocardiumMyosin Binding Protein CProtein DomainsRatsActinsCalciumCarrier ProteinsMyosin Binding Protein CMyosinsC0-C2 calcium sensitivityLength-dependent activationMavacamtenMyosin-binding protein CN-terminal regionTransgenic rat

Identifiers

PMID40068771
PMCPMC13200603

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.