Evidence map›Paper›PMID 40068727›Full record

ArticleClinical immunology (Orlando, Fla.)2025

IL-4 alters TLR7-induced B cell developmental program in lupus.

Changming Lu, Shanrun Liu, Min Gao, Jose Rubio, W Winn Chatham, Hui-Chen Hsu, John D Mountz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Changming LuDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Shanrun LiuDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Min GaoClinical Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jose RubioDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
W Winn ChathamDepartment of Internal Medicine, Kirk Kerkorian School of Medicine, University of Nevada, Las Vegas, Las Vegas, NV 89154, USA.
Hui-Chen HsuDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Medicine Service, Birmingham Veterans Affairs Health Care System, Birmingham, AL, USA. Electronic address: hhsu@uabmc.edu.
John D MountzDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Medicine Service, Birmingham Veterans Affairs Health Care System, Birmingham, AL, USA. Electronic address: jdmountz@uabmc.edu.

Funding

Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
ROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5M
B cell intrinsic interferon-beta regulates autoreactive B cell developmentR01AI134023 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2018 to 2022
$2.4M
AhR suppression of T-bet+ B cells in SLER01AI182085 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI John D Mountz · 2025 to 2026
$1.1M
Multi-parameter, analytic flow cytometerS10OD032296 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RANDALL, TROY D · 2022 to 2022
$464k
BLRD VA I01 BX006099NIAID NIH HHS P30 AI027767NIAID NIH HHS R01 AI134023NIAID NIH HHS R01 AI182085NIAMS NIH HHS P30 AR048311NIH HHS S10 OD032296
6 · The paper itself

Abstract

TLR7 stimulation of T-bet

Indexed as

B-LymphocytesInterleukin-4Lupus Erythematosus, SystemicToll-Like Receptor 7AnimalsAutoantibodiesFemaleGerminal CenterHumansImidazolesMembrane GlycoproteinsMiceAutoantibodiesImidazolesInterleukin-4Membrane GlycoproteinsresiquimodTLR7 protein, humanTlr7 protein, mouseToll-Like Receptor 7autoantibodies(6)B cell(2)IL-4(3)lupus(1)TLR7(4)transcriptomics(5)

Identifiers

PMID40068727
PMCPMC12065647

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.