Associations of HLA-DRB1 shared epitope alleles with cardiovascular disease and events in a multi-ethnic community-living population: The multi-ethnic study of atherosclerosis (MESA).
Manmeet Kaur, Ronit Katz, Michael H Criqui, Maripat Corr, Wendy S Post, Matthew Budoff, Gerald P Morris, Jan M Hughes-Austin
Article in Human immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 · What the graph read from it
What it found
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2 · The registry
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5 · Who and what money
Authors and funding
8 authors.
Manmeet KaurDepartment of Medicine, University of California, San Diego, United States.
Ronit KatzDepartment of Obstetrics & Gynecology, University of Washington, United States.
Michael H CriquiDepartment of Family Medicine and Public Health, University of California, San Diego, United States.
Maripat CorrDepartment of Medicine, University of California, San Diego, United States.
Wendy S PostDivision of Cardiology, Department of Medicine, Johns Hopkins University, United States.
Matthew BudoffDepartment of Medicine, University of California, Los Angeles, United States.
Gerald P MorrisDepartment of Pathology, University of California, San Diego, United States.
Jan M Hughes-AustinDepartment of Orthopaedic Surgery, University of California, San Diego, United States. Electronic address: jhughesaustin@health.ucsd.edu.
Funding
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Multi-Ethnic Study of Autoimmunity and Cardiovascular DiseaseR01HL104047 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MAJKA, DARCY S · 2011 to 2014
$2.0M
Antibodies to Citrullinated Protein Antigens, CVD and Bone Disease in MESAK01HL122394 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HUGHES-AUSTIN, JAN MARIE · 2015 to 2019
$836k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · HC · NORTHWESTERN UNIVERSITY · PI LIU, KIANG JOHN · 1999 to 2001
$511k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095163 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FOLSOM, AARON R · 1999 to 2001
objectiveRheumatoid arthritis (RA) has been considered an independent risk factor for cardiovascular disease (CVD), where RA and CVD later manifest following genetic predisposition and an extended preclinical phase.TheHLA-DRB1Shared Epitope (SE)allelespredispose for RA andare associated withhigherrisk of CV mortality in RA patients, but have not been evaluated in a community-living population.Thus, we evaluated whetherHLA-DRB1 (SE) alleleswereassociated with subclinical CVD, CV events, and mortality in the Multi-Ethnic Study of Atherosclerosis (MESA).
methodsWe performed HLA typing in 955 MESA participants and evaluated associations of SE alleles with coronary artery calcium (CAC) and abdominal aortic calcium (AAC); risk difference for CAC, AAC severity, and carotid intima media thickness (cIMT); and associations of SE with all-cause mortality, CVD and non-CVD death, and CV events.
resultsAmong 955 participants, 30 % were HLA-DRB1 SE positive. SE positivity was not significantly associated with higher risk of CAC, AAC, cIMT, CV events, or mortality. DRB1*10:01 demonstrated 2.63-fold higher risk for CAC (95 % CI 1.17-5.99); DRB1*14:02 demonstrated 42 % higher risk for AAC (95 % CI 1.17-1.74); and DRB1*04:05 demonstrated 24 % lower risk for AAC (95 % CI 0.58-0.99).
conclusionIn a multi-ethnic community-living population, HLA-DRB1 SE alleles were not associated with subclinical CVD, CV events, or mortality. However, individual allele-associations with subclinical CVD suggested variability in risk.
Indexed as
AtherosclerosisCardiovascular DiseasesEpitopesHLA-DRB1 ChainsAgedAged, 80 and overAllelesCarotid Intima-Media ThicknessEthnicityFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedRisk FactorsUnited StatesEpitopesHLA-DRB1 ChainsAutoimmunityCardiovascular diseaseShared epitope
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Associations of HLA-DRB1 shared epitope alleles with cardiovascular disease and events in a multi-ethnic community-living population: The multi-ethnic study of atherosclerosis (MESA). · full record | OpenQuestion