Evidence map›Paper›PMID 40068329›Full record

ArticleRedox biology2025

Estrogen metabolites and hydrogen peroxide - Missing elements in the pathophysiology and possible treatment of treatment-resistant depression?

Zofia Winczewska, Agnieszka Mechlińska, Piotr Radziwiłłowicz, Lucyna Konieczna, Joanna Drzeżdżon, Dagmara Jacewicz, Mariusz Wiglusz, Tomasz Bączek, Wiesław Jerzy Cubała, Magdalena Górska-Ponikowska

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In one paragraph

Article in Redox biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zofia WinczewskaDepartment of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland.
Agnieszka MechlińskaDepartment of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Piotr RadziwiłłowiczDepartment of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Lucyna KoniecznaDepartment of Pharmaceutical Chemistry, Medical University of Gdansk, Gdansk, Poland.
Joanna DrzeżdżonDepartment of Environmental Technology, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308, Gdansk, Poland.
Dagmara JacewiczDepartment of Environmental Technology, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308, Gdansk, Poland.
Mariusz WigluszDepartment of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Tomasz BączekDepartment of Pharmaceutical Chemistry, Medical University of Gdansk, Gdansk, Poland.
Wiesław Jerzy CubałaDepartment of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Magdalena Górska-PonikowskaDepartment of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland; Department of Biophysics, Institute of Biomaterials and Biomolecular Systems, University of Stuttgart, 70569, Stuttgart, Germany; Euro-Mediterranean Institute of Science and Technology, 90139, Palermo, Italy. Electronic address: magdalena.gorska-ponikowska@gumed.edu.pl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenesis of depression is complex and heterogeneous, and the management of this disease remains unsatisfactory, so mechanisms and therapeutic strategies are constantly being sought. This study aimed to determine the potential role of estrogen metabolites in the pathogenesis of treatment-resistant depression (TRD) based on the determination of concentrations of estrogens and their metabolites and hydrogen peroxide (H

Indexed as

Depressive Disorder, Treatment-ResistantEstradiolHydrogen PeroxideAdultAgedFemaleHumansMaleMiddle AgedOxidative StressEstradiolHydrogen Peroxide2-MethoxyestradiolHydrogen peroxideOxidative stressQuinonesReactive oxygen speciesTreatment resistant depression

Identifiers

PMID40068329
PMCPMC11938146

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.