ArticleCornea2025
Influence of Adipose Tissue on Ocular Inflammation.
Article in Cornea, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Obesity and Keratoconus: A Mediation Study Based on the Chinese Keratoconus Cohort.Translational vision science & technology · 2026Article
- BMI moderates the association between physical fitness and spherical equivalent in Chinese college students: a cross-sectional study.Frontiers in public health · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeWe present a case of ocular pathology linked to morbid obesity, emphasizing the role of systemic inflammation in ocular disease and clinical impact of weight loss.
methodsWe report the case of a 49-year-old man with morbid obesity and obstructive sleep apnea who underwent bilateral corneal transplants secondary to keratoconus. For 4 years, he had chronic bulbar hyperemia with progressive blood vessel growth across the graft-host junction, which was treated with chronic topical corticosteroids. Nine years after presentation, he also developed severe papilledema associated with idiopathic intracranial hypertension that proved recalcitrant to treatment with acetazolamide therapy and optic sheath fenestration. Concomitantly, the patient's proinflammatory markers (erythrocyte sedimentation rate, C-reactive protein) were consistently elevated. The patient underwent vertical sleeve gastrectomy, resulting in substantial weight loss. Clinical findings, treatment interventions, and outcomes were documented.Results: The patient experienced marked improvement in corneal graft health and resolution of papilledema following weight loss of 188 pounds. Systemic inflammatory markers, including erythrocyte sedimentation rate and C-reactive protein, also normalized. These findings suggest a correlation between adipose tissue mass and ocular inflammation.
conclusionsOur patient had rapid improvements in his ocular pathology that correlated with a notable reduction in body fat percentage. We propose that the immunological changes associated with obesity contributed to a proinflammatory ocular state that improved with weight loss. His case highlights that additional research is warranted to explore the etiopathogenic mechanisms of adipokines derived from white adipose tissue on major organ systems, including the eye.
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