ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Label-Free Dual-Modal Photoacoustic/Ultrasound Localization Imaging for Studying Acute Kidney Injury.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Photoacoustic Imaging Reveals Early Hemodynamic Changes in Diabetic Nephropathy: Hemoglobin Rise Prior to Oxygen Saturation Drop.Journal of biophotonics · 2026Article
- Can Photoacoustic Imaging Provide a Sensitive Marker for Early Detection of Diabetic Nephropathy.Journal of biophotonics · 2026Article
- Regulated cell death: a multidimensional regulatory network in the pathogenesis of renal fibrosis.Apoptosis : an international journal on programmed cell death · 2026Review
- Photo-activated ultrasound localization imaging with laser-activated nanodroplets.Communications engineering · 2026Article
- EBDE clearing: A strategy for simultaneous 3D visualization and quantitative analysis of both renal arteries and glomeruli.Theranostics · 2026Article
- Photoacoustic imaging assessment of acute kidney injury associated with experimental necrotizing enterocolitis.bioRxiv : the preprint server for biology · 2025Article
- Label-Free Dual-Modal Photoacoustic/Ultrasound Localization Imaging for Studying Acute Kidney Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Advancements in the non-invasive diagnosis of renal fibrosis.Frontiers in medicine · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Growing evidence suggests a close link between acute kidney injury (AKI) and disruptions in renal microcirculation. However, current non-invasive tools for quantitatively monitoring structural and functional changes in renal microcirculation remain limited, making early diagnosis difficult. To address this challenge, this work introduces a label-free 3D multi-parametric imaging technique that combines photoacoustic and super-resolution ultrasound imaging. This approach provides high-resolution information on renal vasculature, hemodynamics, and oxygenation. This system offers the ability to visualize the entire renal vasculature at a resolution of 26 µm. In an AKI model, this work demonstrates a 54% reduction in vascular density, a 14.1% decrease in renal oxygenation, and a 61% decline in relative blood volume (rBV) 3 days post-surgery. The progression of kidney disease is further confirmed through blood tests and histopathological analysis of the collected kidney tissues. These findings indicate that this 3D renal imaging technique holds substantial potential to advance the understanding of renal physiology and offers a valuable tool for investigating renal injury.
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Registered trials
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