ArticleNeurology2025
Underestimation of Follow-Up Infarct Volume by Acute CT Perfusion Imaging.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Baseline imaging for determining infarct core in patients with acute ischemic stroke: noncontrast computed tomography vs computed tomography perfusion.Neuroradiology · 2026Article
- Article
- Automated ischemic stroke lesion detection on non-contrast brain CT: a large-scale clinical feasibility test AI stroke lesion detection on NCCT.Frontiers in neuroscience · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesIt is unknown whether acute CT perfusion (CTP) core imaging may underestimate the follow-up infarct. We hypothesize that infarct underestimation occurs especially in late-presenting patients and that underestimated infarct can partially be detected on baseline noncontrast CT (NCCT).
methodsWe included patients with acute anterior circulation ischemic stroke who underwent baseline NCCT and CTP imaging, complete endovascular reperfusion, and follow-up MRI from the Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke (DEFUSE 3) trial and a consecutive, monocenter cohort. We divided patients into early (<6 hours) and late (6-24 hours) presenters. We performed semiautomated segmentations of the acute ischemic lesion on NCCT using 5% relative density difference (
resultsWe included 109 patients with a median age of 70 (interquartile range [IQR] 31-93) years of whom 52% were female. The follow-up infarct was underestimated by the CTP core (mean absolute volume difference [MAVD] = 14 mL [SD 36], DISCUSSION: Underestimation of follow-up infarct by CTP is substantial and the follow-up infarct can partially be detected by baseline NCCT, especially in patients with stroke with delayed presentation. Combining
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