ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
P21-Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy.
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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
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What it found
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Who cites it
3 citing papers in PubMed.
- Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- P21-Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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Authors and funding
22 authors.
Tao LiKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Ting LiuKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Yan WangKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Yangpeng LiKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Leiying LiuKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China.
James BaeDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
Yu HeDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
Xian LuoKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Zhu LiuKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Tangting ChenKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Xianhong OuKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Dan ZhangKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Huan LanKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Juyi WanDepartment of Cardiology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Yan WeiKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Fang ZhaoDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
Xin WangFaculty of Biology, Medicine and Health, The University of Manchester, Dover Street, Manchester, M13 9GB, UK.
Tao LiLaboratory of Mitochondria and Metabolism, West China Hospital of Sichuan University, Chengdu, 610041, China.
Christopher L-H HuangPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.
Chunxiang ZhangKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Ming LeiKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Xiaoqiu TanKey Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China.ORCID https://orcid.org/0000-0003-0062-6209
Funding
British Heart Foundation PG/14/79/31102British Heart Foundation PG/16/67/32340British Heart Foundation PG/19/59/34582British Heart Foundation PG/21/10512British Heart Foundation PG/22/11217British Heart Foundation PG/23/11479British Heart Foundation RE/18/3/34214Bureau of Science and Technology of Luzhou 2024LZXNYDJ006National Natural Science Foundation of China 31871181National Natural Science Foundation of China 31900813National Natural Science Foundation of China 82270334National Natural Science Foundation of China 82470323Sichuan Science and Technology Program 2022YFS0627Sichuan Science and Technology Program 2024JDHJ0051Sichuan Science and Technology Program 2025HJPJ0005Sichuan Science and Technology Program 2025ZNSFSC0052Sichuan Science and Technology Program 2025ZNSFSC0710
Abstract
Ventricular arrhythmias associated with cardiac adrenergic stress and hypertrophy pose a significant clinical challenge. We explored ventricular anti-arrhythmic effects of P21-activated kinase 2 (Pak2), comparing in vivo and ex vivo cardiomyocyte-specific Pak2 knockout (Pak2
Indexed as
Cardiomegalyp21-Activated KinasesTachycardia, VentricularAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutMyocytes, CardiacOxidative StressReactive Oxygen Speciesp21-Activated KinasesPak2 protein, mouseReactive Oxygen SpeciesCa2+ handlingcardiac arrhythmiamitochondrial oxidative stressNADPH oxidaseP21‐activated kinase 2
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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.