ReviewAnnual review of clinical psychology2025
Reward Processing in Mood Disorders and Schizophrenia: A Neurodevelopmental Framework.
Review in Annual review of clinical psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Temperament, personality, and psychopathology in youth: A preregistered multilevel meta-analytic review and preregistered large-scale replication and extension.Psychological bulletin · 2026Pooled it
- Reward Dysfunction in Time: Toward a Dynamic Psychiatry of Motivation and Pleasure.Biological psychiatry global open science · 2026Article
- Low Reward and Heightened Threat Neural Activity are Both Associated with Heightened Anhedonia: A Transdiagnostic Perspective.Research square · 2026Article
- Translational pathways of oxytocin therapy in schizophrenia: bridging negative symptom domains and neural mechanisms.Translational psychiatry · 2026Review
- Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression.Journal of neurochemistry · 2026Review
- The Cognitive-Affective Social Processing and Emotion Regulation (CASPER) model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Neurocomputational mechanisms of reward-based online mood regulation in adolescents with bipolar disorder and major depressive disorder.Psychoradiology · 2026Article
- Pramipexole treatment and substance use disorder risk in unipolar and bipolar depression: a Swedish nationwide register study.Frontiers in psychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Major depressive disorder (MDD), bipolar disorder, and schizophrenia involve disruptions in processing rewarding stimuli. In this review, we propose that distinct mechanistic pathways underlie these disruptions in mood disorders versus schizophrenia, and we highlight the importance of understanding these differences for developing personalized treatments. We summarize evidence suggesting that reward processing abnormalities in mood disorders are driven by dysregulated motivational systems; MDD is characterized by blunted responses to reward cues, and bipolar disorder is characterized by heightened responses. In contrast, we argue that reward processing disruptions in schizophrenia do not reflect abnormalities in motivation or hedonic experience; rather, they reflect impairments in the cognitive representation of past and future rewards as well as misdirected attention to irrelevant stimuli. To integrate these findings, we present a neurodevelopmental framework for the onset of mood and psychotic disorders and explore how disruptions in normative brain development contribute to their pathophysiology, timing, and onset. Additionally, we move beyond viewing these conditions as homogeneous disorders and discuss how reward processing profiles may align with specific symptom dimensions.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.