Evidence map›Paper›PMID 40067831›Full record

ArticlePloS one2025

Examining safety of cardiac surgery in patients with preoperative cardiac arrest.

Amulya Vadlakonda, Syed Shahyan Bakhtiyar, Shayan Ebrahimian, Sara Sakowitz, Nikhil Chervu, Arjun Verma, Corynn Branche, Khajack Darbinian, Peyman Benharash

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amulya VadlakondaDepartment of Surgery, Center for Advanced Surgical and Interventional Technology, University of California, Los Angeles, California, Unites States of America.
Syed Shahyan BakhtiyarDepartment of Surgery, University of Colorado, Aurora, Colorado, Unites States of America.
Shayan EbrahimianDepartment of Surgery, Center for Advanced Surgical and Interventional Technology, University of California, Los Angeles, California, Unites States of America.ORCID https://orcid.org/0000-0002-6819-4871
Sara SakowitzDepartment of Surgery, Center for Advanced Surgical and Interventional Technology, University of California, Los Angeles, California, Unites States of America.
Nikhil ChervuDepartment of Surgery, Center for Advanced Surgical and Interventional Technology, University of California, Los Angeles, California, Unites States of America.ORCID https://orcid.org/0000-0003-0327-9847
Arjun VermaDepartment of Surgery, Center for Advanced Surgical and Interventional Technology, University of California, Los Angeles, California, Unites States of America.
Corynn BrancheDepartment of Surgery, Center for Advanced Surgical and Interventional Technology, University of California, Los Angeles, California, Unites States of America.
Khajack DarbinianDepartment of Surgery, Center for Advanced Surgical and Interventional Technology, University of California, Los Angeles, California, Unites States of America.
Peyman BenharashDepartment of Surgery, Center for Advanced Surgical and Interventional Technology, University of California, Los Angeles, California, Unites States of America.ORCID https://orcid.org/0000-0002-4705-0262

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough postoperative cardiac arrest is a well-studied complication of cardiac surgery, few guidelines exist regarding timing of surgery in preoperative cardiac arrest (pCA). We examined the association between delayed timing of operation and postoperative outcomes following cardiac surgery in a large cohort of pCA.

methodsAdults with a diagnosis of pCA undergoing a cardiac operation were identified in the 2016-2020 National Inpatient Sample. Those requiring surgery within 24 hours fo cardiac arrest were excluded. Patients who underwent a cardiac procedure after 5 days of cardiopulmonary resuscitation were classified as Delayed (others: Early). Multivariable regression models were constructed to evaluate associations between delayed timing of surgery with in-hospital mortality, postoperative complications, hospitalization duration, and costs.

resultsOf an estimated 9,240 patients meeting study criteria, 4,860 (52.6%) received delayed cardiac surgery. Following entropy balancing, delayed surgery was significantly associated with decreased odds of in-hospital mortality (Adjusted Odds Ratio [AOR] 0.75, 95% Confidence Interval [CI] 0.58 - 0.97). However, delayed operation demonstrated greater odds of postoperative thromboembolic (AOR 1.44, 95% CI 1.02 - 2.04), and infectious (AOR 1.65, 95% CI 1.31 - 2.08) complications. Notably, delay did not alter odds of neurologic complication, and was linked to a decrement in per-day costs (β -$2,100, 95% CI -2,600 - -1,700).

conclusionsWhile preoperative cardiac arrest remains challenging, the present study demonstrates the safety profile of delaying cardiac operation among patients tolerating at least 24 hours of a delay to surgery. Future studies are needed to elucidate the factors associated with favorable outcomes in this population.

Indexed as

Cardiac Surgical ProceduresHeart ArrestPostoperative ComplicationsAdultAgedCardiopulmonary ResuscitationFemaleHospital MortalityHumansLength of StayMaleMiddle Aged

Identifiers

PMID40067831
PMCPMC11896030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.