Evidence map›Paper›PMID 40067775›Full record

ArticleEpigenomics2025

Immigrant status and citizenship relationships with epigenetic aging in a representative sample of United States adults.

Jamaji C Nwanaji-Enwerem, Patricia Rodriguez Espinosa, Dennis Khodasevich, Nicole Gladish, Hanyang Shen, Anne K Bozack, Saher Daredia, Belinda L Needham, David H Rehkopf, Andres Cardenas

Abstract read
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In one paragraph

Article in Epigenomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jamaji C Nwanaji-EnweremDepartment of Emergency Medicine, Center for Health Justice, and Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-0356-4867
Patricia Rodriguez EspinosaDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.
Dennis KhodasevichDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.
Nicole GladishDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.
Hanyang ShenDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.
Anne K BozackDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.
Saher DarediaDivision of Epidemiology, UC Berkeley School of Public Health, Berkeley, CA, USA.
Belinda L NeedhamDepartment of Epidemiology, Center for Social Epidemiology and Population Health, University of Michigan School of Public Health, Ann Arbor, MI, USA.
David H RehkopfDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.
Andres CardenasDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.

Funding

Race/Ethnicity, DNA Methylation, and Disparities in Cardiovascular Mortality: NHANES 1999-2002R01MD011721 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEEDHAM, BELINDA L., REHKOPF, DAVID H · 2017 to 2021
$3.1M
Common and Distinct Influences of Prenatal and Postnatal Early-Life Adversity on Epigenomic Trajectories in Mexican American ChildrenR01MD016595 · NIMHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI Andres Cardenas, Julianna Deardorff · 2022 to 2026
$3.0M
PRENATAL AND POSTNATAL EXPOSURE TO ENVIRONMENTAL MIXTURES: NEURODEVELOPMENT AND DNA METHYLATION BIOMARKERSR01ES031259 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CARDENAS, ANDRES · 2020 to 2024
$1.9M
NIEHS NIH HHS R01 ES031259NIMHD NIH HHS R01 MD011721NIMHD NIH HHS R01 MD016595
6 · The paper itself

Abstract

backgroundImmigrant status and citizenship influence health and well-being, yet their associations with DNA methylation (DNAm)-based biomarkers of aging - key predictors of healthspan and lifespan, also known as epigenetic aging - remain underexplored.

methodsUsing a representative sample of 2,336 United States (U.S.) adults from the 1999-2000 and 2001-2002 cycles of the National Health and Nutrition Examination Survey (NHANES), we analyzed cross-sectional associations of immigrant status and U.S. citizenship with seven epigenetic aging biomarkers: HannumAge, HorvathAge, SkinBloodAge, PhenoAge, GrimAge2, DNAm Telomere Length, and DunedinPoAm.

resultsAfter adjusting for demographic factors, immigrants had 2.53-year lower GrimAge2 measures (95%CI: -3.44, -1.63,

conclusionOur results support the paradigm of the immigrant mortality advantage and highlight the potential value of epigenetic age measures in studying socioeconomic and broader factors influencing citizen and immigrant health.

Indexed as

AgingEmigrants and ImmigrantsEpigenesis, GeneticAdultAgedBiomarkersCross-Sectional StudiesDNA MethylationFemaleHumansMaleMiddle AgedNutrition SurveysUnited StatesBiomarkersADMCRPDNA methylation ageimmigrant healthnational health and nutrition examination survey (NHANES)

Identifiers

PMID40067775
PMCPMC11970729

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.