ReviewAdvances in experimental medicine and biology2025
Age-Related Thymic Involution.
Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Disrupted drainage in the aging brain: Meningeal lymphatic decline as a convergent axis of vulnerability.Neurobiology of aging · 2026Review
- Integrative transcriptomic and proteomic profiling reveals altered thymocyte development and microenvironment remodeling during natural thymic atrophy.Frontiers in cell and developmental biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The age-related thymic involution has intrigued scientists since its first observations. This phenomenon is well-conserved across different species, but the reason why it exists is not clear since the thymus is a key organ in the immune system responsible for the maturation of immunocompetent T lymphocytes. As thymic function declines with age, it significantly affects the health of older individuals, leading to reduced responses to new pathogens, tumor cells, and vaccines. This impact was notably evident during the COVID-19 pandemic, where a substantial number of elderly individuals succumbed to the disease. This chapter explores the characteristics of age-related thymic involution, including new findings using recently developed technologies. We also highlight emerging research trends aimed at rejuvenating thymus function.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.