Evidence map›Paper›PMID 40067583›Full record

ReviewAdvances in experimental medicine and biology2025

Thymus Ontogeny and Development.

Sara Montero-Herradón, Javier García-Ceca, Agustín G Zapata

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sara Montero-HerradónDepartment of Cell Biology. Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.
Javier García-CecaDepartment of Cell Biology. Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.
Agustín G ZapataDepartment of Cell Biology. Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain. zapata@ucm.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The thymus is a primary lymphoid organ composed of a three-dimensional (3D) epithelial network that provides a specialized microenvironment for the phenotypical and functional maturation of lymphoid progenitors. The specification of the pharyngeal endoderm to thymus fate occurs during the early stages of thymic organogenesis, independent of the expression of the transcription factor Foxn1. However, Foxn1 governs the later organogenesis of thymus together with the colonizing lymphoid cells. In the present chapter, we will review recent evidence on the topic covered in our original chapter (Muñoz and Zapata 2019). It described the early development of thymus and its resemblance to the development of endoderm-derived epithelial organs based on tubulogenesis and branching morphogenesis as well as the molecules known to be involved in these processes.

Indexed as

OrganogenesisThymus GlandAnimalsCell DifferentiationEndodermForkhead Transcription FactorsGene Expression Regulation, DevelopmentalHumansForkhead Transcription FactorsWhn protein

Identifiers

PMID40067583

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.