Evidence map›Paper›PMID 40067562›Full record

ReviewSeminars in immunopathology2025

NK cells: shielding senescence homeostasis in the decidua during early pregnancy.

Zi-Meng Zheng, Jia-Wei Shi, Li Wang, Ming-Qing Li

Abstract readReview
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In one paragraph

Review in Seminars in immunopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zi-Meng ZhengDepartment of Reproductive Immunology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People's Republic of China.
Jia-Wei ShiDepartment of Reproductive Immunology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People's Republic of China.
Li WangReproductive Medical Center, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People's Republic of China.
Ming-Qing LiDepartment of Reproductive Immunology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People's Republic of China. mqli@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-9276-0722

Funding

Chu Ying Project of the International Peace Maternity and Child Health Hospital CYJH2413Key Technologies Research and Development Program 2023YFC2705403National Natural Science Foundation of China 32370914, 92478122, 92357306Natural Science Foundation of Shanghai Municipality 23ZR1408200Open Fund for Shanghai Key Laboratory of Embryo Original Diseases shelab2024ZD02Shanghai Oriental Talent Plan
6 · The paper itself

Abstract

Decidualization, the transformation of endometrial stromal cells into specialized decidual cells, is essential for embryo implantation and pregnancy maintenance. This process involves immune cell infiltration, especially decidual natural killer (dNK) cells, which regulate immune responses and support tissue remodeling. Recent findings suggest that cellular senescence during decidualization is not just a byproduct but plays a functional role in enhancing uterine receptivity. However, excessive senescence leads to complications like recurrent pregnancy loss. dNK cells help maintain decidual homeostasis by clearing senescent cells, preventing their harmful accumulation. The balance between dNK activity and decidual stromal cell (DSC) senescence is crucial for successful implantation and pregnancy outcomes. Disruption of this balance may contribute to pathological conditions. This review delves into the pivotal roles of dNK cells in decidual senescence regulation and discusses therapeutic strategies targeting senescence to improve pregnancy outcomes, and new approaches for treating reproductive disorders.

Indexed as

Cellular SenescenceDeciduaHomeostasisKiller Cells, NaturalAnimalsEmbryo ImplantationFemaleHumansPregnancyStromal CellsCellular senescenceDecidualizationNK cellRecurrent pregnancy lossSenescence-associated secretory phenotype

Identifiers

PMID40067562

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.