Evidence map›Paper›PMID 40067456›Full record

ArticleLung2025

SIRT2 Regulates Apoptosis Signaling in Hyperoxic Acute Lung Injury.

Yu Jin Lee, Mi Na Kim, Eun Gyul Kim, Chang Hyun Park, Joo Yeon Cho, Byung Chan Ko, Min Jung Kim, Yoon Hee Kim, Soon Min Lee, Kyung Won Kim and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Lung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yu Jin Lee *Department of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50-1, Yonsei-Ro Seodaemun-Gu, Seoul, South Korea.
Mi Na Kim *Department of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50-1, Yonsei-Ro Seodaemun-Gu, Seoul, South Korea.
Eun Gyul KimDepartment of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50-1, Yonsei-Ro Seodaemun-Gu, Seoul, South Korea.
Chang Hyun ParkDepartment of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50-1, Yonsei-Ro Seodaemun-Gu, Seoul, South Korea.
Joo Yeon ChoDepartment of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50-1, Yonsei-Ro Seodaemun-Gu, Seoul, South Korea.
Byung Chan KoDepartment of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50-1, Yonsei-Ro Seodaemun-Gu, Seoul, South Korea.
Min Jung KimDepartment of Pediatrics, Yongin Severance Hospital, Yonsei University College of Medicine, 363 Dongbaekjukjeon-Daero Giheung-Gu, Yongin, South Korea.
Yoon Hee KimDepartment of Pediatrics, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Soon Min LeeDepartment of Pediatrics, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Kyung Won KimDepartment of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50-1, Yonsei-Ro Seodaemun-Gu, Seoul, South Korea.
Tae Won SongDepartment of Pediatrics, Ilsan Paik Hospital, Inje University College of Medicine, 170 Juhwa-Ro, Ilsanseo-Gu, Goyang, 10380, South Korea.
Myung Hyun SohnDepartment of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50-1, Yonsei-Ro Seodaemun-Gu, Seoul, South Korea. mhsohn@yuhs.ac.

Funding

National Research Foundation of Korea NRF-2018R1A5A2025079National Research Foundation of Korea NRF-2022R1F1A1064545
6 · The paper itself

Abstract

purposeOxygen therapy is helpful for patients with breathing difficulties; however, sustained supplementation with high-concentration oxygen can cause hyperoxic acute lung injury. Sirtuin 2 (SIRT2), a nicotinamide adenine dinucleotide (NAD

methodsWild-type (WT) mice and SIRT2-deficient (SIRT2

resultsSIRT2 expression was elevated in WT mice after hyperoxic exposure. We also observed that the levels of SIRT2 were higher in tracheal aspirates from newborns with bronchopulmonary dysplasia (BPD) than in those without BPD. Hyperoxia-induced inflammation and apoptosis were more considerably attenuated in SIRT2

conclusionTaken together, SIRT2 plays a critical role in the pathogenesis of hyperoxic acute lung injury by regulating apoptotic signaling. These findings indicated that SIRT2 is potentially a novel therapeutic strategy for hyperoxic acute lung injury.

Indexed as

Acute Lung InjuryApoptosisBronchopulmonary DysplasiaHyperoxiaLungSirtuin 2AcetylationAnimalsDisease Models, AnimalForkhead Box Protein O3HumansInfant, NewbornMaleMiceMice, Inbred C57BLMice, KnockoutForkhead Box Protein O3FoxO3 protein, mouseSirt2 protein, mouseSirtuin 2Acute lung injuryApoptosisDeacetylationFOXO3HyperoxiaSIRT2

Identifiers

PMID40067456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.