ArticleNaunyn-Schmiedeberg's archives of pharmacology2025
Caffeine and sclareol take the edge off the sedative effects of linalool, possibly through the GABAA interaction pathway: molecular insights through in vivo and in silico studies.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Exploring Linalool-Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition.Phytotherapy research : PTR · 2026Review
- Complexed Linalool with Beta-Cyclodextrin Improve Antihypertensive Activity: Pharmacokinetic and Pharmacodynamic Insights.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Sedative potential of palmatine chloride in thiopental sodium-induced chicks: evidence from in vivo and in Silico studies.Scientific reports · 2025Article
- Genetic Divergence and Functional Significance of Bioactive Compounds in Rice and Barley: Implications for Biofortification and Human Health.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Linalool (LIN) has some important neuropharmacological activities, including anxiolytic and sedative effects. It is also clear that it protects experimental animals from convulsions and Alzheimer's disease. On the other hand, caffeine (CAF) and sclareol (SCL) have neurostimulatory potential. This study evaluates the sedative effect and possible molecular mechanisms of CAF with LIN and/or SCL through in vivo and in silico studies. For this, CAF (10 mg/kg) alone or with LIN (50 mg/kg) and/or SCL (10 mg/kg) was intraperitoneally (i.p.) treated before thirty minutes of thiopental sodium (TS) injection (40 mg/kg, i.p.) to the mice and observed for latency and duration of sleep up to 4 h. To understand the possible action mechanisms of these drugs, we also performed molecular docking and pharmacokinetics profile studies with gamma-aminobutyric acid (GABA
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.