Evidence map›Paper›PMID 40067401›Full record

SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Cervical intramedullary spinal cord metastasis from colon cancer: a systematic review and report of an illustrative case.

Nicola Montemurro, Tamara Ius, Valerio Ortenzi, Francesco Pasqualetti, Francesco Acerbi

Abstract readSystematic ReviewCase Reports
PubMed Publisher
In one paragraph

Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicola MontemurroDepartment of Neurosurgery, Azienda Ospedaliero Universitaria Pisana (AOUP), Pisa, Italy. nicola.montemurro@unipi.it.ORCID http://orcid.org/0000-0002-3686-8907
Tamara IusHead-Neck and Neurosciences Department, Santa Maria Della Misericordia University Hospital, Udine, Italy.ORCID http://orcid.org/0000-0003-3741-0639
Valerio OrtenziDepartment of Laboratory Medicine, Azienda Ospedaliero Universitaria Pisana (AOUP), Pisa, Italy.
Francesco PasqualettiDepartment of Surgery, Oncology and Gastroenterology - DiSCOG, University of Padua, Padua, Italy.
Francesco AcerbiDepartment of Neurosurgery, Azienda Ospedaliero Universitaria Pisana (AOUP), Pisa, Italy.ORCID http://orcid.org/0000-0002-4063-3924

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntramedullary spinal cord metastasis (ISCM) is rare and affects 0.9-2.1% of all cancer patients. Colorectal cancer accounts for about 3% of all ISCMs.

methodsA systematic review of the literature in the most common electronic database (PubMed, Ovid MEDLINE and Ovid EMBASE) on cervical ISCM from colon cancer, according with "PRISMA statement" criteria, was done. In addition, we present a 76-year-old man with progressive paraparesis and negative anamnesis for primary tumors, who underwent surgical and complete resection of a C5-C6 intramedullary spinal cord colon metastasis.

resultsFrom a systematic review of the literature, only 8 previous cases of cervical ISCM from colon cancer were reported. The mean age at presentation was 68.3 years. Surgery was performed in 6 patients, including our case, whereas 1 patient was treated with radiotherapy and two patients were untreated. Survival time ranges from 2 weeks to 14 months (mean 3.8 months). The survival rates at 60 days and 120 days are 50% and 12.5%, respectively.

conclusionCervical ISCM from colon cancer is rare and is usually detected at an advanced stage of primary tumor disease. The prognosis is poor and definitive recommendations cannot be made due to the lack of controlled comparative clinical studies.

Indexed as

Colonic NeoplasmsSpinal Cord NeoplasmsAgedCervical VertebraeHumansMaleColon cancer metastasisIntramedullary spinal cord lesionIntramedullary spinal cord metastasis

Identifiers

PMID40067401

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.