ArticleInternational forum of allergy & rhinology2025
Differential Immune Cell Infiltration in Eosinophilic and Non-Eosinophilic CRS: Correlations With Clinical, Endoscopic, and Radiological Findings.
Article in International forum of allergy & rhinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Oral Steroid Use and Asthma Comorbidity in Central Compartment Atopic Disease: The Predictive Role of Olfactory Dysfunction and Eosinophilia.International forum of allergy & rhinology · 2026Article
- Mycoplasma pneumoniae infection impairs asthma control in pediatric patients and exacerbates allergic airway inflammation.Respiratory research · 2026Article
- Immune-inflammatory endotypes of chronic rhinosinusitis: from epithelial alarmins to personalized therapy.Frontiers in immunology · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe pathogenesis of inflammation in eosinophilic chronic rhinosinusitis (ECRS) and non-eosinophilic chronic rhinosinusitis (NECRS) remains poorly understood. This study aimed to assess immune cell infiltration within the sinonasal microenvironment in these conditions.
methodsA prospective case-controlled study was conducted to evaluate the expression of CD3, CD11b, CD16, and CD19 in CRS. Sinonasal mucosal sections from patients with ECRS (n = 18), NECRS (n = 27), and normal controls (n = 12) were analyzed by immunohistochemistry. Preoperative clinical data, including sinonasal symptoms, allergy and asthma status, endoscopic Lund‒Kennedy score, radiological Lund‒Mackay score, and peripheral blood morphological parameters, were collected. Expression profiles were then correlated with clinical data.
resultsSignificant differences were observed in the number of CD11b-positive and CD19-positive cells between ECRS and NECRS patients, as well as in the number of CD3-positive cells in CRS groups compared to controls. In ECRS patients, a positive correlation was found between the expression of CD16-positive and CD11b-positive cells. Additionally, elevated B-cell expression in this group was associated with olfactory dysfunction and the radiological severity of lesions.
conclusionOur study reveals distinct inflammatory patterns in ECRS and NECRS and provides new insights into the underlying mechanisms of CRS. The assessment of CD11b, CD16, and CD19 expression could potentially serve as biomarkers to predict treatment response, especially in patients undergoing monoclonal antibody therapy.
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