Evidence map›Paper›PMID 40067106›Full record

Observational studyRadiology2025

Comparison of Contrast-enhanced Mammography and Low-Energy Imaging with or without Supplemental Whole-Breast US in Breast Cancer Detection.

Joao V Horvat, Tali Amir, Gordon P Watt, Christopher E Comstock, Noam Nissan, Maxine S Jochelson, Janice S Sung

Abstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joao V Horvat *From the Departments of Radiology (J.V.H., T.A., C.E.C., N.N., M.S.J., J.S.S.) and Epidemiology and Biostatistics (G.P.W.), Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-5699-2094
Tali Amir *From the Departments of Radiology (J.V.H., T.A., C.E.C., N.N., M.S.J., J.S.S.) and Epidemiology and Biostatistics (G.P.W.), Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-7004-7793
Gordon P WattFrom the Departments of Radiology (J.V.H., T.A., C.E.C., N.N., M.S.J., J.S.S.) and Epidemiology and Biostatistics (G.P.W.), Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-2024-0015
Christopher E ComstockFrom the Departments of Radiology (J.V.H., T.A., C.E.C., N.N., M.S.J., J.S.S.) and Epidemiology and Biostatistics (G.P.W.), Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-6303-3940
Noam NissanFrom the Departments of Radiology (J.V.H., T.A., C.E.C., N.N., M.S.J., J.S.S.) and Epidemiology and Biostatistics (G.P.W.), Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-5416-4199
Maxine S JochelsonFrom the Departments of Radiology (J.V.H., T.A., C.E.C., N.N., M.S.J., J.S.S.) and Epidemiology and Biostatistics (G.P.W.), Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-4012-2470
Janice S SungFrom the Departments of Radiology (J.V.H., T.A., C.E.C., N.N., M.S.J., J.S.S.) and Epidemiology and Biostatistics (G.P.W.), Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-9067-9840

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Background Contrast-enhanced mammography (CEM) is an emerging modality that generates low-energy (LE) images that are visually equivalent to full-field digital mammography (FFDM) and recombined images that show lesion vascularity such as MRI. Supplemental whole-breast US increases cancer detection rates when performed with FFDM but not with MRI. Purpose To compare the performance of CEM, LE images, and LE images supplemented with whole-breast US in breast cancer detection during screening. Materials and Methods This prospective study recruited female participants from December 2014 to February 2019 who were scheduled for screening mammography and whole-breast US. CEM (including LE images and recombined images) and whole-breast US images were interpreted by separate breast radiologists blinded to the findings on images from the other modality. Statistical differences in sensitivity and specificity, positive predictive value (PPV), negative predictive value, and abnormal interpretation rate were assessed. Biopsy recommendation rate and PPVs of biopsies performed (PPV

Indexed as

Breast NeoplasmsContrast MediaMammographyUltrasonography, MammaryAdultAgedBreastFemaleHumansMiddle AgedProspective StudiesSensitivity and SpecificityContrast Media

Identifiers

PMID40067106
PMCPMC11950873

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.