ArticleChemistry & biodiversity2025
Antioxidants and Antidiabetic Potential of Polyphenolic Fractions and Crude Extracts of Rhus typhina Fruit, Punica granatum L. Peel, and Terminalia catappa L. Leaves: In Vitro and In Vivo Evaluation.
Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Rhus typhina (sumac) fruit, Punica granatum (pomegranate) peel, and Terminalia catappa (Indian almond) leaves' extracts and their anthocyanin and non-anthocyanin fractions were assessed in vitro for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferric reducing power (FRAP), human salivary amylase (HAS), and dipeptidyl peptidase IV (DPP-IV) inhibitory potentials, as well as for their in vivo antidiabetic effects on high-sugar high-fat diet (HSHFD) + streptozotocin (STZ) induced diabetic rats (8-weeks study), by assessing fasting blood sugar, 1 h- and 2 h-oral glucose tolerance tests, serum insulin, homeostatic model assessment (HOMA) analyses, serum creatinine, urea, and blood urea nitrogen. Phytochemical analysis revealed that sumac extract had the highest total phenolic content, total flavonoid content, and total anthocyanin content followed by pomegranate peel and almond leaves. All extracts and fractions showed antioxidant (DPPH and FRAP) and enzyme (HAS and DPP-IV) inhibition activities and also suppressed STZ effects in diabetic mice by increasing superoxide dismutase, glutathione S-transferase, and insulin, as well as by decreasing HOMA2-IR, urea, and creatinine, with sumac extract showing benefits even when administered prior to STZ. In addition, in vivo results showed that sumac fruit extract significantly improved glycemic control by reducing fasting blood sugar, enhancing insulin secretion, and improving insulin resistance. These findings suggest that all tested extracts, particularly sumac, possess significant antioxidant, phytochemical, and antidiabetic potential.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.