Evidence map›Paper›PMID 40067051›Full record

Observational studyEuropean journal of neurology2025

Intracerebral Hemorrhage in Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts and Leukoencephalopathy.

Fangwei Hu, Weijie Xie, Mengting Fan, Yuanrong Wang, Shuyan Xu, Wenxin Qiu, Tao Yang, Huimin Lv, Huiqing Huang, Yijia Wu and 2 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04318119 (Cerebral Small Vessel Disease Registry Study), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04318119 recruitingnot on this map

Cerebral Small Vessel Disease Registry Study

Typeobservational_patient_registrySponsorBin CaiRan2019 to 2055Enrolled3,000ConditionsCerebral Small Vessel Diseases
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fangwei HuDepartment of Neurology and Institute of Neurology, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Weijie XieDepartment of Neurology and Institute of Neurology, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Mengting FanDepartment of Neurology and Institute of Neurology, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Yuanrong WangDepartment of Neurology and Institute of Neurology, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Shuyan XuDepartment of Neurology and Institute of Neurology, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Wenxin QiuDepartment of Neurology and Institute of Neurology, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Tao YangDepartment of Neurology and Institute of Neurology, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Huimin LvDepartment of Neurology and Institute of Neurology, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Huiqing HuangDepartment of Neurology and Institute of Neurology, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Yijia WuDepartment of Neurology and Institute of Neurology, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Ying FuDepartment of Neurology and Institute of Neurology, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.ORCID 0000-0002-1590-3945
Bin CaiDepartment of Neurology and Institute of Neurology, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.ORCID 0000-0003-2659-9376

Funding

Joint Funds for the innovation of science and Technology, Fujian province 2018Y9084Joint Funds for the innovation of science and Technology, Fujian province 2023Y9039National Natural Science Foundation of China 82071277National Natural Science Foundation of China 82471299
6 · The paper itself

Abstract

backgroundCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel disease (CSVD). Intracerebral hemorrhage (ICH) is reported to be increasing in CADASIL patients from areas where the p.R544C mutation is prevalent (e.g., Jeju and Chinese Taiwan) but is rare in Caucasians. We attempted to determine potentially genetic, clinical, and/or neuroimaging risk factors for ICH in Chinese CADASIL patients.

methodsThis retrospective observational study included 190 patients with CADASIL and 179 patients with sporadic CSVD. NOTCH3 genotypes as well as clinical and neuroimaging manifestations were compared between ICH and non-ICH patients, and both logistic regression and a subgroup analysis were used to adjust for confounding factors.

resultsOf 190 CADASIL patients in the present study, 43 patients (22.6%) had ICH lesions. A total of 62 ICH lesions were recorded. Thalamic ICH lesions were the most common (40.3%), followed by basal ganglia (32.3%) and temporal lobe (8.1%). In subgroup analysis, the ICH group had a higher prevalence of CMB than the non-ICH group, including in the basal ganglia region (58.3% vs. 23.3%, p = 0.037) and thalamus (75.0% vs. 38.3%, p = 0.020). The p.R544C mutation (aOR 6.390; 95% CI, 1.308-31.225; p = 0.022) and total SVD score (aOR 1.731; 95% CI, 1.003-2.990; p = 0.049) were independently associated with ICH.

conclusionsICH is a common clinical manifestation of CADASIL patients in southeast coastal China. Hypertension, total SVD score, and the p.R544C mutation are associated with CADASIL ICH.

trial registrationClinicalTrials.gov identifier: (NCT04318119).

Indexed as

CADASILCerebral HemorrhageAdultAgedFemaleHumansMaleMiddle AgedMutationReceptor, Notch3Receptors, NotchRetrospective StudiesRisk FactorsNOTCH3 protein, humanReceptor, Notch3Receptors, NotchCADASILhypertensionintracerebral hemorrhagep.R544C mutationrisk factors

Identifiers

PMID40067051
PMCPMC11894821

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.