Evidence map›Paper›PMID 40066998›Full record

ArticlemBio2025

Deficiency in peptidoglycan recycling promotes β-lactam sensitivity in

Malvika Modi, Deepika Chauhan, Michael C Gilmore, Felipe Cava, Richa Priyadarshini

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. mBio · 2026
    Article
  3. bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Malvika ModiDepartment of Life Sciences, School of Natural Sciences, Shiv Nadar Institution of Eminence, Gautam Buddha Nagar, Uttar Pradesh, India.
Deepika ChauhanDepartment of Life Sciences, School of Natural Sciences, Shiv Nadar Institution of Eminence, Gautam Buddha Nagar, Uttar Pradesh, India.
Michael C GilmoreLaboratory for Molecular Infection Medicine Sweden, Department of Molecular Biology, Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden.ORCID 0000-0002-6848-5134
Felipe CavaLaboratory for Molecular Infection Medicine Sweden, Department of Molecular Biology, Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden.ORCID 0000-0001-5995-718X
Richa PriyadarshiniDepartment of Life Sciences, School of Natural Sciences, Shiv Nadar Institution of Eminence, Gautam Buddha Nagar, Uttar Pradesh, India.ORCID 0000-0002-8613-9438

Funding

Department of Science and Technology, Ministry of Science and Technology, India IF180902KAW FoundationScience and Engineering Research Board CRG/2021/003598The Swedish Research Council
6 · The paper itself

Abstract

Peptidoglycan (PG)-modifying enzymes play a crucial role in cell wall remodeling, essential for growth and division. Cell wall degradation products are transported to the cytoplasm and recycled back in most gram-negative bacteria, and PG recycling is also linked to β-lactam resistance in many bacteria.

Indexed as

Anti-Bacterial Agentsbeta-Lactam Resistancebeta-LactamsCaulobacter crescentusPeptidoglycanBacterial ProteinsCell WallGlycosyltransferasesMembrane Transport ProteinsAmpG protein, BacteriaAnti-Bacterial AgentsBacterial Proteinsbeta-LactamsGlycosyltransferasesMembrane Transport ProteinsPeptidoglycanantibiotic resistanceCaulobacter crescentuscell wallpeptidoglycan recyclingβ-lactam

Identifiers

PMID40066998
PMCPMC11980594

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.