SynthesisMicrosurgery2025
Objectifying Clinical Outcomes After Lymphaticovenous Anastomosis and Vascularized Lymph Node Transfer in the Treatment of Extremity Lymphedema: A Systematic Review and Meta-Analysis.
Synthesis in Microsurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy of vascularized lymph node transfer for lower extremity lymphedema: A systematic review and meta-analysis of 395 patients from 25 peer-reviewed studies.Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 2026Pooled it
- Robotic-assisted lymphovenous anastomosis to treat periorbital lymphedema and systematic review of lymphatic reconstruction of face and neck lymphedema.Journal of robotic surgery · 2025Pooled it
- [Effectiveness of lymphaticovenular anastomosis combined with perioperative targeted drainage in treatment of secondary lower limb lymphedema: a prospective randomized trial].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Trial
- Article
- Effectiveness of Home-Based Progressive Resistance Exercise in the Management of Breast Cancer-Related Lymphedema: A Randomized Controlled Trial.Journal of clinical medicine · 2026Article
- Lymphovenous Bypass: Past, Present, and Future.Archives of plastic surgery · 2026Article
- Integrated Microsurgical Rehabilitation Using Deep Inferior Epigastric Perforator Flap Breast Reconstruction Combined With Vascularized Lymph Node Transfer and Abdominoplasty.Plastic and reconstructive surgery. Global open · 2026Article
- Article
- Prolongation of Postoperative Drainage Time in Indocyanine Green Lymphography as a Potential Marker for Lymphedema Development-A Prospective Pilot Study.Journal of clinical medicine · 2026Article
- The role of orthoplastic surgery in musculoskeletal oncology.EFORT open reviews · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUpper extremity lymphedema (UEL) and lower extremity lymphedema (LEL) can develop as a result of lymph node dissection in the treatment of various malignancies. While emerging microsurgical interventions using lymphaticovenous anastomosis (LVA) and vascularized lymph node transfer (VLNT) show promising outcomes for patients with lymphedema, the best approach to implementing the two procedures remains to be defined. This systematic review and meta-analysis provide a comprehensive overview of published literature on the clinical improvement of extremity lymphedema in patients who undergo either LVA, VLNT, or a combined microsurgical procedure.
methodsFrom Embase, PubMed, and Web of Science databases, 52 studies were identified that met inclusion criteria. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The risk of bias was assessed using the Risk Of Bias In Nonrandomized Studies-of Interventions (ROBINS-I) tool and the Cochrane tool for randomized trials (RoB 2).
resultsRandom-effects meta-analyses of means estimated a pooled clinical improvement of 36.46% (95% CI: 29.44-43.48) for UEL and 34.16% (95% CI: 23.93-44.40) for LEL. Subgroup analyses revealed differences in clinical improvement according to the microsurgical approach. Clinical improvement of UEL was 29.44% (95% CI: 15.58-43.29) for LVA, 41.66% (95% CI: 34.13-49.20) for VLNT, and 32.80% (95% CI: 21.96-43.64) for combined VLNT + LVA, while the improvement of LEL was 31.87% (95% CI: 18.60-45.14) for LVA and 39.53% (95% CI: 19.37-59.69) for VLNT.
conclusionThe findings from this study elucidate the clinical improvement in extremity lymphedema from various microsurgical approaches. This knowledge could aid physicians in the shared decision-making process with UEL and LEL patients and better facilitate proper patient selection for microsurgical interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.