Evidence map›Paper›PMID 40066871›Full record

ArticleJournal of the American Society for Mass Spectrometry2025

The Role of Nanobubbles in Protein Unfolding during Electrothermal Supercharging.

George Joseph, Bincy Binny, Andre R Venter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

George JosephDepartment of Chemistry, Western Michigan University, Kalamazoo, Michigan, 49008-5413, United States.ORCID 0009-0005-4952-2197
Bincy BinnyDepartment of Chemistry, Western Michigan University, Kalamazoo, Michigan, 49008-5413, United States.ORCID 0009-0005-7080-9408
Andre R VenterDepartment of Chemistry, Western Michigan University, Kalamazoo, Michigan, 49008-5413, United States.ORCID 0000-0001-6912-7446

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanobubbles (NBs) are tiny gas cavities with diameters around 200 nm that remain stable in solution due to their unique properties, including low buoyancy and negative surface charges. Ammonium bicarbonate (ABC) is an alternative buffer to commonly used ammonium acetate during protein analysis by electrospray ionization (ESI) mass spectrometry. The addition of ABC under high voltage and temperature conditions can lead to protein unfolding, a phenomenon termed electrothermal supercharging (ETS). The role of CO

Indexed as

ProteinsProtein UnfoldingBicarbonatesCarbon DioxideCytochromes cMyoglobinNitrogenSpectrometry, Mass, Electrospray IonizationUbiquitinammonium bicarbonateBicarbonatesCarbon DioxideCytochromes cMyoglobinNitrogenProteinsUbiquitinelectrothermal superchargingflow regime switchingnanobubblesprotein unfoldingTesla valve

Identifiers

PMID40066871
PMCPMC11969647

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.