Evidence map›Paper›PMID 40066809›Full record

ArticleThe Journal of infectious diseases2025

Genomic Epidemiology of Resurgent Hepatitis A in Florida, 2018-2022.

Timothy J Doyle, Brian H Buck, Timothy J Locksmith, Brenna M McGruder-Rawson, Yury Khudyakov, Carina Blackmore

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Timothy J DoyleDivision of Disease Control and Health Protection, Florida Department of Health, Tallahassee, Florida, USA.ORCID 0000-0002-4501-9157
Brian H BuckDivision of Disease Control and Health Protection, Florida Department of Health, Tallahassee, Florida, USA.ORCID 0000-0001-5802-9461
Timothy J LocksmithDivision of Disease Control and Health Protection, Florida Department of Health, Tallahassee, Florida, USA.
Brenna M McGruder-RawsonDivision of Disease Control and Health Protection, Florida Department of Health, Tallahassee, Florida, USA.
Yury KhudyakovDivision of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Carina BlackmoreDivision of Disease Control and Health Protection, Florida Department of Health, Tallahassee, Florida, USA.

Funding

CDC HHS NU50CK000554CDC HHS NU90TP922058Intramural CDC HHS CC999999NCEZID CDC HHS U01 CK000554
6 · The paper itself

Abstract

During 2018-2022, a resurgence of hepatitis A occurred in Florida, with 5491 cases reported. Genotyping was performed on a convenience sample of cases through amplification and sequencing of the hepatitis A virus VP1-P2B junction region. Virus isolates from 1190 cases (22%) were genotyped; 69% were subgenotype IB, 30% were subgenotype IA, and 1% were subgenotype IIIA. Subgenotype IB was more common among patients reporting recent drug use or homelessness, whereas IA was more common among those reporting recent international travel and among men who have sex with men. Genotype IB infection was associated with a more than 4-fold greater odds of death compared to IA infection. A network analysis revealed 11 genomic clusters of ≥10 cases, with distinct temporal and spatial distributions. Case reports in 2023 decreased to below pre-2018 numbers, likely due to high population immunity following natural infection and extensive vaccination activities in the highest-risk groups.

Indexed as

Hepatitis AHepatitis A virusHepatitis A Virus, HumanAdolescentAdultAgedChildFemaleFloridaGenome, ViralGenomicsGenotypeHumansMaleMiddle AgedMolecular EpidemiologyepidemiologyFloridagenotypehepatitisviruses

Identifiers

PMID40066809
PMCPMC12452135

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.