Evidence map›Paper›PMID 40066709›Full record

ArticleAnnals of medicine2025

Impact of parathyroid gland classification on hypoparathyroidism following total thyroidectomy with central neck dissection for differentiated thyroid cancer.

Qixuan Sheng, Wei Li, Ping Zhang, Qiang Wang, Siluo Zha, Wensheng Rao, Bin Wang, Xinyun Xu, Ming Qiu, Wei Zhang and 1 more

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Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Qixuan ShengDepartment of Thyroid, Breast and Hernia Surgery of Changzheng Hospital affiliated to Naval Military Medical University, Shanghai, China.
Wei LiDepartment of Thyroid, Breast and Hernia Surgery of Changzheng Hospital affiliated to Naval Military Medical University, Shanghai, China.
Ping ZhangDepartment of Thyroid, Breast and Hernia Surgery of Changzheng Hospital affiliated to Naval Military Medical University, Shanghai, China.
Qiang WangDepartment of Thyroid, Breast and Hernia Surgery of Changzheng Hospital affiliated to Naval Military Medical University, Shanghai, China.
Siluo ZhaDepartment of Thyroid, Breast and Hernia Surgery of Changzheng Hospital affiliated to Naval Military Medical University, Shanghai, China.
Wensheng RaoDepartment of Thyroid, Breast and Hernia Surgery of Changzheng Hospital affiliated to Naval Military Medical University, Shanghai, China.
Bin WangDepartment of Thyroid, Breast and Hernia Surgery of Changzheng Hospital affiliated to Naval Military Medical University, Shanghai, China.
Xinyun XuDepartment of Thyroid, Breast and Hernia Surgery of Changzheng Hospital affiliated to Naval Military Medical University, Shanghai, China.
Ming QiuDepartment of Thyroid, Breast and Hernia Surgery of Changzheng Hospital affiliated to Naval Military Medical University, Shanghai, China.
Wei ZhangDepartment of Thyroid, Breast and Hernia Surgery of Changzheng Hospital affiliated to Naval Military Medical University, Shanghai, China.
Chengxiang ShanDepartment of Thyroid, Breast and Hernia Surgery of Changzheng Hospital affiliated to Naval Military Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the impact of parathyroid gland (PG) classification on hypoparathyroidism incidence following total thyroidectomy (TT) with central neck dissection (CND) in patients with differentiated thyroid carcinoma (DTC).

methodsIn this prospective cohort study, adult patients with DTC who underwent TT with CND between 2021 and 2023 were enrolled, with a maximum follow-up duration of 32 months. A simplified PG classification system was employed, categorizing glands into four distinct types: tightly connected, loosely connected, non-connected, and thymic. The intraoperative frequency of each PG type was recorded based on this classification. Parathyroid hormone (PTH) levels were routinely tested 1 day, 1 month, 6 months and 1 year after surgery. The association between PG classification and the incidence of postoperative hypoparathyroidism was then systematically analysed.

resultsAmong 135 patients with DTC (mean age: 48.50 ± 10.52 years; 101 women), 62 patients (45.93%) developed hypoparathyroidism on postoperative day 1 (POD1), while 14 patients (10.37%) experienced hypoparathyroidism on postoperative month 1 (POM1). All patients exhibited PTH normalization within six months, with no permanent hypoparathyroidism cases. A total of 532 PGs were identified: 264 (49.62%) were tightly connected, 150 (28.20%) loosely connected, 95 (17.86%) non-connected, and 23 (4.32%) thymic. The highest prevalence of hypoparathyroidism on POD1 was observed in patients with four tightly connected PGs (

conclusionPG classification may serve as a valuable tool for surgeons in intraoperative parathyroid preservation and the prediction of postoperative hypoparathyroidism in patients with DTC. Notably, DTC patients with more than two tightly connected PGs are at an elevated risk of developing temporary hypoparathyroidism, emphasizing the importance of meticulous parathyroid preservation during surgical procedures.

Indexed as

HypoparathyroidismNeck DissectionParathyroid GlandsPostoperative ComplicationsThyroidectomyThyroid NeoplasmsAdultFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedParathyroid HormoneProspective StudiesParathyroid Hormoneclassificationdifferentiated thyroid cancerHypoparathyroidismparathyroid glands

Identifiers

PMID40066709
PMCPMC11899267

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.