Evidence map›Paper›PMID 40066450›Full record

ArticleFrontiers in immunology2025

Case Report: MOGAD - a steroid-responsive autoimmune meningoencephalitis mimicking infection.

Yihui Goh, Priscillia Pei Shi Lye, Paul Anantharajah Tambyah, Derek Tuck Loong Soon, Nares Smitasin, Jonathan Jia Yuan Ong, Clement Hsiang Rong Yong, Yee Cheun Chan, David Tang, Kay Wei Ping Ng and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yihui GohDivision of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore.
Priscillia Pei Shi LyeDivision of Infectious Diseases, Department of Medicine, National University Hospital, Singapore, Singapore.
Paul Anantharajah TambyahDivision of Infectious Diseases, Department of Medicine, National University Hospital, Singapore, Singapore.
Derek Tuck Loong SoonDivision of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore.
Nares SmitasinDivision of Infectious Diseases, Department of Medicine, National University Hospital, Singapore, Singapore.
Jonathan Jia Yuan OngDivision of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore.
Clement Hsiang Rong YongDepartment of Diagnostic Imaging, National University Hospital, Singapore, Singapore.
Yee Cheun ChanDivision of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore.
David TangDivision of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore.
Kay Wei Ping NgDivision of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore.
Raymond Chee Seong SeetDivision of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore.
Amy May Lin QuekDivision of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case series reports three patients initially managed for presumed infectious meningoencephalitis, who were ultimately diagnosed with myelin oligodendrocyte glycoprotein associated disease (MOGAD). Their clinical presentations were strikingly similar to those of acute infectious meningoencephalitis, which posed a challenge to the initial diagnostic process. Notably, despite the absence of typical radiological changes associated with MOGAD, such as cerebral cortical encephalitis, these patients exhibited focal neurological and electroencephalographic changes. This series highlights the importance of considering MOG antibody testing in cases of aseptic meningoencephalitis, where early and accurate diagnosis can influence treatment decisions and patient outcomes in this steroid-responsive condition.

Indexed as

Adrenal Cortex HormonesMeningoencephalitisMyelin-Oligodendrocyte GlycoproteinMyelin Oligodendrocyte Glycoprotein Antibody-Associated DiseaseAdultAutoantibodiesDiagnosis, DifferentialElectroencephalographyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedAdrenal Cortex HormonesAutoantibodiesMOG protein, humanMyelin-Oligodendrocyte Glycoproteinaseptic meningoencephalitisautoimmunecerebral cortical encephalitisMOGADMOG-IgG

Identifiers

PMID40066450
PMCPMC11891045

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.