Evidence map›Paper›PMID 40066435›Full record

ArticlePaediatric & neonatal pain2025

Objective Detection of Newborn Infant Acute Procedural Pain Using EEG and Machine Learning Algorithms.

Jean-Michel Roué, Amir Avnit, Behnood Gholami, Wassim M Haddad, Kanwaljeet J S Anand

Abstract read
In one paragraph

Article in Paediatric & neonatal pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Artificial intelligence in pediatric pain: a systematic review.BMC medical informatics and decision making · 2026
    Pooled it
  2. Review
  3. Review
  4. Automated Deep Learning Approach for Post-Operative Neonatal Pain Detection and Prediction through Physiological Signals.Proceedings. IEEE International Symposium on Computer-Based Medical Systems · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jean-Michel RouéDepartment of Neonatal Medicine and Pediatric Critical Care, University Hospital of Brest University of Brest Brest France.ORCID https://orcid.org/0000-0002-5734-7254
Amir AvnitAutonomous Healthcare Inc. Santa Clara California USA.
Behnood GholamiAutonomous Healthcare Inc. Santa Clara California USA.
Wassim M HaddadSchool of Aerospace Engineering Georgia Institute of Technology Atlanta Georgia USA.
Kanwaljeet J S AnandDepartment of Pediatrics, Anesthesiology, Perioperative and Pain Medicine Stanford University, School of Medicine Stanford California USA.ORCID https://orcid.org/0000-0001-6498-1483

Funding

Developing AI-Driven Pain Intensity and Pain Sensitization Biomarker Signatures to Optimize Neonatal Pain ManagementUG3NS138882 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI ANAND, KANWALJEET S, HO, THAO · 2024 to 2024
$1.3M
A Multimodal Approach for Monitoring Prolonged Acute Pain in NeonatesR21NR018756 · NINR · UNIVERSITY OF SOUTH FLORIDA · PI SUN, YU · 2020 to 2021
$401k
Measuring Infant Pain Objectively using Sensor Fusion and Machine Learning AlgorithmsR41DA046983 · NIDA · AUTONOMOUS HEALTHCARE, INC. · PI GHOLAMI, BEHNOOD · 2018 to 2018
$225k
NIDA NIH HHS R41 DA046983NINDS NIH HHS UG3 NS138882NINR NIH HHS R21 NR018756
6 · The paper itself

Abstract

Observer-dependent infant pain scales have limitations including discontinuous assessments and the lack of healthcare professionals' availability. We hypothesized that applying agnostic machine learning approaches to neonatal electroencephalographic (EEG) analysis may reveal features of the infant response to acute pain. EEG was recorded from 30 neonates undergoing acutely painful procedures (18 males, 34.0-41.7 weeks gestation at birth). EEG recordings were randomly assigned to training (

Indexed as

EEGmachine learningnewborn infantpain assessment

Identifiers

PMID40066435
PMCPMC11891568

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.