Evidence map›Paper›PMID 40066431›Full record

ArticleIndian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India2025

The Impact of Primary Tumor Volume on Survival of Patients with Non-Surgically Treated Advanced-Stage Hypopharyngeal Cancer- Retrospective Study and Literature Overview.

Sasa Jakovljevic, Vladimir Djordjevic, Nada Tomanovic, Nenad Arsovic, Zoran Dudvarski, Tamara Ursulovic, Darko Laketic, Katarina Jovanovic, Konstantin Arsovic, Nemanja Radivojevic

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Article in Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sasa JakovljevicFaculty of Medicine, University of Belgrade, Deligradska 9, Belgrade, 11000 Serbia.ORCID 0000-0002-5410-3078
Vladimir DjordjevicFaculty of Medicine, University of Belgrade, Deligradska 9, Belgrade, 11000 Serbia.
Nada TomanovicFaculty of Medicine, University of Belgrade, Deligradska 9, Belgrade, 11000 Serbia.
Nenad ArsovicFaculty of Medicine, University of Belgrade, Deligradska 9, Belgrade, 11000 Serbia.
Zoran DudvarskiFaculty of Medicine, University of Belgrade, Deligradska 9, Belgrade, 11000 Serbia.
Tamara UrsulovicInstitute for Oncology and Radiology of Serbia, Belgrade, Serbia.
Darko LaketicFaculty of Medicine, University of Belgrade, Deligradska 9, Belgrade, 11000 Serbia.
Katarina JovanovicClinic of Otorhinolaryngology and Maxillofacial Surgery, University Clinical Center of Serbia, Belgrade, Serbia.
Konstantin ArsovicClinic of Otorhinolaryngology and Maxillofacial Surgery, University Clinical Center of Serbia, Belgrade, Serbia.
Nemanja RadivojevicFaculty of Medicine, University of Belgrade, Deligradska 9, Belgrade, 11000 Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To determine the prognostic value of tumor volume in predicting the survival in patients with stage III-IV of hypopharyngeal carcinoma. We studied 71 patients with advanced stage of hypopharyngeal carcinoma. The volume of primary tumor was calculated by approximation of the ellipsoid volume. Correlation between carcinoma volume and demographic, clinical and carcinoma characteristics has shown that male patients and patients consuming alcohol had greater tumor volumes. The median of overall survival was at 12 months (95% CI: 9.25-14.75); the median of progression-free survival was at 9 months (95% CI: 6.6-11.3). ROC Curve Analysis of carcinoma volumes in outcome prediction shows that the cutoff of 14.69 had the sensitivity of 61% and specifics of 89%. Based on significant independent impact of tumor volume on survival, it is important to include this parameter among possible new treatment protocols.

Indexed as

Advanced hypopharyngeal cancerCancer prognosisNon-surgical treatmentSurvivalTumor volume

Identifiers

PMID40066431
PMCPMC11890697

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.