Evidence map›Paper›PMID 40066211›Full record

ArticleCirculation reports2025

A Novel Missense Variant of

Ryotaro Asano, Makoto Okazawa, Tomohiko Ishibashi, Xin Ding, Keiko Ohta-Ogo, Kotaro Akaki, Saori Umeki-Mizushima, Akiko Yamagishi, Tadakatsu Inagaki, Ai Yaku and 6 more

Abstract read
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In one paragraph

Article in Circulation reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ryotaro Asano *Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute Osaka Japan.
Makoto Okazawa *Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute Osaka Japan.
Tomohiko Ishibashi *Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute Osaka Japan.
Xin DingDepartment of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute Osaka Japan.
Keiko Ohta-OgoDepartment of Pathology, National Cerebral and Cardiovascular Center Hospital Osaka Japan.
Kotaro AkakiDepartment of Medical Chemistry, Graduate School of Medicine, Kyoto University Kyoto Japan.
Saori Umeki-MizushimaDepartment of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute Osaka Japan.
Akiko YamagishiDepartment of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute Osaka Japan.
Tadakatsu InagakiDepartment of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute Osaka Japan.
Ai YakuDepartment of Medical Chemistry, Graduate School of Medicine, Kyoto University Kyoto Japan.
Shinya FujisakiDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center Hospital Osaka Japan.
Takatoyo KikoDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center Hospital Osaka Japan.
Kinta HatakeyamaDepartment of Pathology, National Cerebral and Cardiovascular Center Hospital Osaka Japan.
Osamu TakeuchiDepartment of Medical Chemistry, Graduate School of Medicine, Kyoto University Kyoto Japan.
Takeshi OgoDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center Hospital Osaka Japan.
Yoshikazu NakaokaDepartment of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute Osaka Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Because Regnase-1, encoded by Methods and Results: We analyzed whole-genome sequence data of patients with PAH to search for disease-associated Conclusions: We identified a novel missense variant of

Indexed as

GeneticsInflammationPulmonary arterial hypertension

Identifiers

PMID40066211
PMCPMC11890303

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.