Evidence map›Paper›PMID 40066201›Full record

ArticleToxicology reports2025

Preconception exposure to perfluorooctanesulfonic acid (PFOS) and perfluorobutanesulfonic acid (PFBS) impaired reproduction via insulin/insulin-like growth factor signaling pathway without effects on the second generation in

Sida Li, Yiren Yue, Zhuojia Qian, Zixuan Teng, John M Clark, Alicia R Timme-Laragy, Yeonhwa Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Progeny effects of rotenone exposure depend on parental toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sida LiDepartment of Food Science, University of Massachusetts, Amherst, MA 01003, United States.
Yiren YueDepartment of Food Science, University of Massachusetts, Amherst, MA 01003, United States.
Zhuojia QianDepartment of Food Science, University of Massachusetts, Amherst, MA 01003, United States.
Zixuan TengDepartment of Food Science, University of Massachusetts, Amherst, MA 01003, United States.
John M ClarkDepartment of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, United States.
Alicia R Timme-LaragyDepartment of Environmental Health Sciences, University of Massachusetts, Amherst, MA 01003, United States.
Yeonhwa ParkDepartment of Food Science, University of Massachusetts, Amherst, MA 01003, United States.

Funding

Toxicant disruption of receptor-mediated endocytosis in oogenesis and later life metabolic dysfunctionR01ES028201 · NIEHS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI TIMME-LARAGY, ALICIA R · 2017 to 2021
$2.1M
NIEHS NIH HHS R01 ES028201
6 · The paper itself

Abstract

In previous studies, preconception exposure to perfluorooctanesulfonic acid (PFOS) and perfluorobutanesulfonic acid (PFBS) reduced the reproductive capacity and altered the development of the offspring of

Indexed as

Caenorhabditis elegansPFBSPFOSReproductive toxicity

Identifiers

PMID40066201
PMCPMC11891744

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.